Review of Active Compounds from Medicinal Plants with Antihyperglycemic Efficiency on Translocation and Expression of Glucose Transporter 4 on Muscle and Adipose Tissue
DOI:
https://doi.org/10.22270/ajprd.v10i4.1159Keywords:
Antihyperglycemic, GLUT4, active compounds, Glucose TransportersAbstract
Glucose transporter’s mechanism is influenced by the presence of insulin, especially GLUT4 which acts on muscle, adipose, and brain tissue. Medicinal plants with active compounds that were able to regulate the expression and translocation of GLUT helps in the treatment of insulin resistance and hyperglycemia. This study aimed to determine which active compounds isolated from medicinal plants have antihyperglycemic activity on GLUT4 expression in muscle and adipose tissue. The research method used was by searching the literature electronically with the keywords "Plant Isolation", "Chemical Compounds", "Antihyperglycemic Activity", and "Glucose transporter (GLUT) 4". Literature sources in the form of international and national journals have been found on several sites, such as NCBI, Elsevier and Pubmed, and others. A literature search in the form of selected journals from 2016 to 2021. The data were analyzed using the PRISMA (Prefered Reporting Items for Systematic Review and Meta-analyses) method. The results showed that the active substances contained in the plant have antihyperglycemic activity by increasing the translocation and expression of GLUT4 in skeletal muscle cells, adipocytes, and tested-animal models of DM.
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References
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16. Bao Q, Shen X, Qian L, Gong C, et al. Antidiabetic activities of catalpol in db/db mice. Korean J Physiol Pharmacol. 2016; 20 (2):153-160.
17. Fang P, He B, Yu M. et al. Treatment with celastrol protects against obesity through suppression of galanin induced fat intake and activation of PGC-1α/GLUT-4 axis-mediated glucose consumption. BBA-Molecular Basis of Disease. 2019; 1865:1341-1350.
18. Banu GS. Cucurbitacin augments insulin sensitivity and glucose uptake through translocation and activation of GLUT-4 in PI3K/ALT signalling pathway. World Journal of Pharmaceutical Research. 2017; 6:1078-1096.
19. Gao YF, Zhang MN, Wang TX, et al. Hypoglycemic effect of D-chiroinositol in type 2 diabetes mellitus rats through the PI3K/Akt signalling pathway. Molecular and Cellular Endocrinology. 2016; 433:26-34.
20. Hsu CC, Lin MH, Cheng JT, et al. Antihyperglycemic action of diosmin, a citrus flavonoid induced through endogenous β endorphin in type I-like diabetic rats. Clinical and Experimental Pharmacology and Physiology. 2017; 44:549-555.
21. Lin CH, Kuo YH, Shih CC. Eburicoic Acid, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects in Palmitate-Treated C2C12 Myotubes and in High-Fat Diet-Fed Mice. International Journal of Molecular Sciences. 2017; 18:1-29.
22. Boue SM, Daogle KW, Chen MH, et al. Antidiabetic potential of purple and red rice (Oryza sativa L) Bran extracts. Journal of Agricultural and Food Chemistry. 2016; 64:5345-5353.
23. Variya BC, Bakrania AK, Patel SS. Antidiabetic potential of gallic acid from Emblica officinalis: Improved glucose transporters and insulin sensitivity through PPAR-γ and Akt signalling. Phytomedicine. 2019; 73:1-11.
24. Samad MB, Mohsin NAB, Razu BA, et al. [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucosestimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/ RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice.BMC Complementary and Alternative Medicine. 2017; 17:1-13.
25. Meng Q, Qi X, Chen Q, Cheng P, et al. Flavonoids extracted from mulberry (Morus alba L) leaf improve skeletal muscle mitochondrial function by activating AMPK in type 2 diabetes. Journal of Ethnopharmacology. 2020; 10(248):112326.
26. Aziz SMA, Ahmed OM, El Twab SMA, et al. Antyhiperglycemic effects and mode of actions of Musa paradisiaca Leaf and Fruit peel hydroethanolic extract in nicotinamide/ Streptozotocin induced diabetic rats. Evidence Based Complementary and alternative Medicine. 2020:1-15.
27. Singh AK, Raj V, Keshari AK, et al. Isolated mangiferin and naringenin exert antidiabetic effect via PPARγ/ GLUT4 dual agonistic action with strong metabolic regulation. Chemico Biological Interaction. 2018; 280:33-44.
28. Silva FC, Romero LC, Duran LA, et al. Antidiabetic effect of Achillea millefollium through multitarget interactions α-glucosidases inhibition, insulin sensitization and insulin secretagogue activities. Journal of Ethnopharmacology. 2018; 212:1-7.
29. Ahmed OM, Hassan, MA, Twab SMA, et al. Navel orange pell hydroethanolic extract, naringin and naringenin have anti-diabetic potentials in type 2 diabetic rats. Biomedicine and Pharmacotherapy. 2017; 94:197-205.
30. Giacometti J, Muhvic D, Kezele TG, et al. Olive leaf plyphenols (OLPs) stimulate GLUT-4 expression and translocation in the skeletal muscle of diabetic rats. International Journal of Molecular Sciences. 2020; 21:1-30.
31. Shen X, Zhou N, Mi L, et al. Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro. Drug design, Development and Therapy. 2017; 11:313-324.
32. Maeda A, Shirao T, Shirasaya D, et al. Piperine Promotes Glucose Uptake through ROS-Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle. Molecular Nutrition Food Research. 2018; 62:1-11.
33. Les F, Mainar JMA, Valero MS, et al. Pomegranate polyphenols and urolithin A inhibit α-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells. Journal of Ethnopharmacology. 2018; 220:67-74.
34. Yamashita Y, Wang L, Nanba F, et al. Procyanidin Promotes Translocation of Glucose Transporter 4 in Muscle of Mice through Activation of Insulin and AMPK Signaling Pathways. Journal Plos One. 2016; 11(9):1-19.
35. Dehghan F, Hajiaghaalipour F, Yusof A, et al. Saffron with resistance exercise improves diabetic parameters through the GLUT4/AMPK pathway in-vitro and in-vivo. Scientific Reports. 2016; 6:1-12.
36. Jang JH, Park JE, Han JS. Scopoletin increase glucose uptake through activation of PI3K and AMPK signalling pathway and improve insulin sensitivity in 3t3-L1 cells. Nutrition Research. 2020; 74:52-61.
37. Rai U, Kosuru R, Prakash S, et al. Tetramethylpyrazine prevents diabetes by activating PI3K/Akt/GLUT-4 signalling in animal model of type-2 diabetes. Life Sciences. 2019; 236:1-11.
38. Udomkiri NK, Toejing P, Sirilun S, et al. Antihyperglycemic effect of rice husk derived xylooligosaccharides in high fat diet and low dose streptozotocin induced type 2 diabetic rat model. Food Science and Nutrition. 2019; 8:428-444.
2. International Diabetes Federation. 2013. Diabetes Evidence Demands Real Action From The Un Summit On Non-Communicable Diseases. [http://www.idf.org/diabetes-evidence-demands-real-action-un-summit-non-communicable-diseases] [acces in 28 Juli 2020]
3. Zierath JR, He L, Gumà A, Wahlstrom EO, Klip A, Wallberg-Henriksson H. Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM. Diabetologia. 1996; 39:1180-1189.
4. Shah K, Desilva S and Abbruscato T. The Role of Glucose Transporters in Brain Disease: Diabetes and Alzheimer’s Disease. International Journal of Molecular Science. 2012; 12(10):12629-12655.
5. Olson AL. Regulation of GLUT4 and Insulin-dependent Glucose Flux. International Scholarly Research Network Molecular Biology. 2012:1-12.
6. Wu YC, Hsu JH, Liu IM, Liou SS, Su HC, Cheng JT. Increase of Insulin Sensitivity in Diabetic Rats Received Die-Huang-Wan. A Herbal Mixture Used in Chinese Traditional Medicine. Acta Pharmacologica Sinica. 2001; 23(12):1181 – 1187.
7. Jafri AA, Sharma SB, Khurana N, et al. Herbal Anti-Hyperglycemic Compound Increases Expression of Glucose Transporter Molecules in Diabetic Rats. Journal of Diabetes and Metabolism. 2019; 10(3):1-7.
8. Bao S, Wu YL, Wang X, Han S. Agriophyllum oligosaccharides ameliorate hepatic injury in type 2 diabetic db/db mice targeting INS-R/IRS-2/PI3K/AKT/PPAR-γ/GLUT-4 signal pathway.Journal of Ethnopharmacology. 2020; 257:1-9.
9. Kuo, YH, Lin CH, Shih CC, et al. Antcin-K, a triterpenoid compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects via Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in Muscles. Evidence Based Complementary and Alternative Medicine. 2016:1-16.
10. Min W, Wu M, Fang P, et al. Effect of Baicalein on GLUT4 Translocation in Adipocytes of Diet-Induced Obese Mice. Cellular Physiology and Biochemistry. 2018. 50:426-436.
11. Kuo YT, Lin CC, Kuo HT, et al. Identification of baicalin from bofutsushosan and Daisaikoto as a potent inducer of glucose uptake and modulator of insulin signalling associated pathway. Journal of Food and Drugs Analysis. 2018:1-9.
12. Fang P, Yu M, Min W, et al. Effect of baicalin on GLUT-4 expression and glucose uptake in myotubes of rats. Life Sciences. 2018; 196:156-161.
13. Lee H, Li H, Noh M, et al. Bavachin from Psoralea corylifolia improves insulin dependent glucose uptake through insulin signalling and AMPK activation in 3T3-Li adipocytes. International Journal of Molecular Sciences. 2016; 17:1-12.
14. Hironao KY, Ashida H, Yamashita Y. The cacao procyanidin extract caused antihyperglycemic effect was changed by the administration timings. J Clin Biochem Nutr. 2020; 11(9):1-6.
15. Vlavcheski F, Baron D, Vlachogiannis IA, et al. Carnosol Increases Skeletal Muscle Cell Glucose Uptake via AMPK-Dependent GLUT4 Glucose Transporter Translocation. International Journal of Molecular Sciences. 2018; 19(5):1-15.
16. Bao Q, Shen X, Qian L, Gong C, et al. Antidiabetic activities of catalpol in db/db mice. Korean J Physiol Pharmacol. 2016; 20 (2):153-160.
17. Fang P, He B, Yu M. et al. Treatment with celastrol protects against obesity through suppression of galanin induced fat intake and activation of PGC-1α/GLUT-4 axis-mediated glucose consumption. BBA-Molecular Basis of Disease. 2019; 1865:1341-1350.
18. Banu GS. Cucurbitacin augments insulin sensitivity and glucose uptake through translocation and activation of GLUT-4 in PI3K/ALT signalling pathway. World Journal of Pharmaceutical Research. 2017; 6:1078-1096.
19. Gao YF, Zhang MN, Wang TX, et al. Hypoglycemic effect of D-chiroinositol in type 2 diabetes mellitus rats through the PI3K/Akt signalling pathway. Molecular and Cellular Endocrinology. 2016; 433:26-34.
20. Hsu CC, Lin MH, Cheng JT, et al. Antihyperglycemic action of diosmin, a citrus flavonoid induced through endogenous β endorphin in type I-like diabetic rats. Clinical and Experimental Pharmacology and Physiology. 2017; 44:549-555.
21. Lin CH, Kuo YH, Shih CC. Eburicoic Acid, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects in Palmitate-Treated C2C12 Myotubes and in High-Fat Diet-Fed Mice. International Journal of Molecular Sciences. 2017; 18:1-29.
22. Boue SM, Daogle KW, Chen MH, et al. Antidiabetic potential of purple and red rice (Oryza sativa L) Bran extracts. Journal of Agricultural and Food Chemistry. 2016; 64:5345-5353.
23. Variya BC, Bakrania AK, Patel SS. Antidiabetic potential of gallic acid from Emblica officinalis: Improved glucose transporters and insulin sensitivity through PPAR-γ and Akt signalling. Phytomedicine. 2019; 73:1-11.
24. Samad MB, Mohsin NAB, Razu BA, et al. [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucosestimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/ RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice.BMC Complementary and Alternative Medicine. 2017; 17:1-13.
25. Meng Q, Qi X, Chen Q, Cheng P, et al. Flavonoids extracted from mulberry (Morus alba L) leaf improve skeletal muscle mitochondrial function by activating AMPK in type 2 diabetes. Journal of Ethnopharmacology. 2020; 10(248):112326.
26. Aziz SMA, Ahmed OM, El Twab SMA, et al. Antyhiperglycemic effects and mode of actions of Musa paradisiaca Leaf and Fruit peel hydroethanolic extract in nicotinamide/ Streptozotocin induced diabetic rats. Evidence Based Complementary and alternative Medicine. 2020:1-15.
27. Singh AK, Raj V, Keshari AK, et al. Isolated mangiferin and naringenin exert antidiabetic effect via PPARγ/ GLUT4 dual agonistic action with strong metabolic regulation. Chemico Biological Interaction. 2018; 280:33-44.
28. Silva FC, Romero LC, Duran LA, et al. Antidiabetic effect of Achillea millefollium through multitarget interactions α-glucosidases inhibition, insulin sensitization and insulin secretagogue activities. Journal of Ethnopharmacology. 2018; 212:1-7.
29. Ahmed OM, Hassan, MA, Twab SMA, et al. Navel orange pell hydroethanolic extract, naringin and naringenin have anti-diabetic potentials in type 2 diabetic rats. Biomedicine and Pharmacotherapy. 2017; 94:197-205.
30. Giacometti J, Muhvic D, Kezele TG, et al. Olive leaf plyphenols (OLPs) stimulate GLUT-4 expression and translocation in the skeletal muscle of diabetic rats. International Journal of Molecular Sciences. 2020; 21:1-30.
31. Shen X, Zhou N, Mi L, et al. Phloretin exerts hypoglycemic effect in streptozotocin-induced diabetic rats and improves insulin resistance in vitro. Drug design, Development and Therapy. 2017; 11:313-324.
32. Maeda A, Shirao T, Shirasaya D, et al. Piperine Promotes Glucose Uptake through ROS-Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle. Molecular Nutrition Food Research. 2018; 62:1-11.
33. Les F, Mainar JMA, Valero MS, et al. Pomegranate polyphenols and urolithin A inhibit α-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells. Journal of Ethnopharmacology. 2018; 220:67-74.
34. Yamashita Y, Wang L, Nanba F, et al. Procyanidin Promotes Translocation of Glucose Transporter 4 in Muscle of Mice through Activation of Insulin and AMPK Signaling Pathways. Journal Plos One. 2016; 11(9):1-19.
35. Dehghan F, Hajiaghaalipour F, Yusof A, et al. Saffron with resistance exercise improves diabetic parameters through the GLUT4/AMPK pathway in-vitro and in-vivo. Scientific Reports. 2016; 6:1-12.
36. Jang JH, Park JE, Han JS. Scopoletin increase glucose uptake through activation of PI3K and AMPK signalling pathway and improve insulin sensitivity in 3t3-L1 cells. Nutrition Research. 2020; 74:52-61.
37. Rai U, Kosuru R, Prakash S, et al. Tetramethylpyrazine prevents diabetes by activating PI3K/Akt/GLUT-4 signalling in animal model of type-2 diabetes. Life Sciences. 2019; 236:1-11.
38. Udomkiri NK, Toejing P, Sirilun S, et al. Antihyperglycemic effect of rice husk derived xylooligosaccharides in high fat diet and low dose streptozotocin induced type 2 diabetic rat model. Food Science and Nutrition. 2019; 8:428-444.
Published
2022-08-14
How to Cite
Widyasti, J. H., Kurniasari, F., & Nugroho, R. B. (2022). Review of Active Compounds from Medicinal Plants with Antihyperglycemic Efficiency on Translocation and Expression of Glucose Transporter 4 on Muscle and Adipose Tissue. Asian Journal of Pharmaceutical Research and Development, 10(4), 70–75. https://doi.org/10.22270/ajprd.v10i4.1159
Issue
Section
Review Articles
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