FORMULATION AND EVALUATION OF ITRACONAZOLE NIOSOMAL GEL
DOI:
https://doi.org/10.22270/ajprd.v6i5.425Keywords:
Niosome, Itraconazole, Cholesterol, Span 60/ Span 40, Diethyl Ether, Carbopol 940, Glycerol, Rotary Vacuum Evaporator.Abstract
The preparation of niosomes. The main objective of the study was to enhance the antifungal activity of the formulation. Itraconazole is a broad spectrum Imidazole derivative useful in the treatment of superfacial and systemic fungal infection. Various surfactants used were span 40 and span 60. Niosomes were prepared by using Rotary Vaccum evaporation method. Niosomes were prepared using different ratio of drug: surfactant: cholesterol (1:1:1, 1:2:1, 1:3:1).Evaluation of the Niosomal gel was done by determination of drug content 52.81-56.12, Entrapment Efficiency 42.20-45.20,Niosomal gel was prepared using Carbopol 940 (1.5%), Glycerol (10%), Triethanolamine (q.s.) and distilled water up to 15ml. Viscosity was determined by Brookfield programmable ultra-viscometer and the ranges 8173 centipoise. The drug content of the Itraconazole niosomal gel was determined at 262 nm against blank by using UV/visible spectrophotometer and found to be 56.12%. The percentage of drug entrapment in niosomal gel was calculated to be 45.20% .The in-vitro drug release study was carried out using phosphate buffer saline pH 7.4 and was found to be 41.18 ± 1.53% for 12 hours. It can be concluded that the gel formulation containing niosomes loaded with Itraconazole showed prolonged action than formulation containing Itraconazole in non-niosomal form and it can be developed successfully to improve the anti-fungal activity.
Downloads
References
2. Biswal S, Murthy PN and Sahu J. Vesicles of Non-ionic Surfactants (Niosomes) and Drug Delivery Potential. Int J Pharm Sci Nanotechnol. 2008;1(1),342-356.
3. Kumar A, Pal JL, Jaiswal A, Singh V. Review on Niosomes as Novel Drug Delivery System. International Research Journal of Pharmacy.2011; 3(1)61-65.
4. Hao YM, Li K. Entrapment and release difference resulting from hydrogen bonding interactions in niosome. Internatinal Journal Pharmaceutics. 2011;403: 245‑53.
5. Sharma S.K, Chauhan M, Kumar A. Span-60 Niosomal Oral Suspension of Fluconazole: Formulation and In Vitro Evaluation.JPRHC.2010; 142-156.
6. Saurabh B, Chandan PK, Geeta A and Harikumar SL. A comparative review on vesicular drug delivery system and stability issues.International Journal of research in pharmacy and chemistry. 2012; 2(3): 704- 713.
7. Balakrishan P et.al.Formulation and in-vitro assessment of Minoxidil niosomes for enhanced skin delivery.International Journal of Pharmaceutics.2014; 377: 1-8.
8. Samyuktha Rani B, Vedha Hari BN. Niosomal formulation of Orlistat: Formulation and in-vitro evaluation. International Journal of Drug Development and Research. 2011; 3(3): 300-311.
9. Shirsand SB, Para MS, Nagendra kumar D, Kanani KM, Keerthy D. Formulation and evaluation of Ketoconazole niosomal gel drug delivery system. Int J Pharm Investig. 2012; 2(4): 201-107.
10. Vyas SP, Khar RK. Targeted and controlled drug delivery novel carrier systems. New delhi. Cbs publishers and distributors.2004; 40: 3-13.
11. Anbarasan B, Rekha S, Elango K, Shriya B, Ramaprabhu S. Optimization of the formulation and in-vitro evaluation of capecitabine niosomes for the treatment of color cancer. IJPSR. 2013; 4(4): 504-1513.
12. Sabarikumar K, Varatharajan P, Sheema MS. Bioavailability enhancement of Aceclofenac niosomes containing surfactants and cholesterol. International Journal of Biological and Pharmaceutical Research. 2012; 3(3): 354-359.
13. Rajera R, Nagpal K, Kumar S, Mishra DN. Niosomes: A controlled and novel drug delivery system. Biol. Pharm Bull. 2011; 34(7): 945-953.
14. Bhaskaran S, Panigrahi L, Formulation and evaluation of niosomes using different non-ionicsurfactant. Ind J Pharm Sci .2002; 63.
15. Kumar A, Pal J and Jaiswal A. Review on niosomes as novel drug delivery system. Int Res J Pharm. 2011;2(5):61-65.
16. Ali N, Harikumar SL and Kaur A. Niosomes: An excellent tool for drug delivery. IJRPC. 2012;2(2):479-486.
Published
How to Cite
Issue
Section
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).