An Overview of Nanogel –Novel Drug Delivery System

Authors

  • Saloni Jain Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India
  • Rahul Kumar Ancheria Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India
  • Saumya Shrivastava Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India
  • Shankar Lal Soni Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India
  • Mukesh Sharma Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India

DOI:

https://doi.org/10.22270/ajprd.v7i2.482

Keywords:

Nanogel, Novel Drug Delivery,Mechanism

Abstract

Nanogels are innovative drug delivery system that can play an integral part in pointing out many issues related to old and modern courses of treatment such as nonspecific effects and poor stability. Biomedical and pharmaceutical applications of Nanogels have been explored for tissue regeneration, wound healing, surgical device, implantation, and peroral, rectal, vaginal, ocular, and transdermal drug delivery. Nanogels are proficiently internalized by the target cells, avoid accumulating in nontarget tissues thereby lower the therapeutic dosage and minimize harmful side effects. Nanogels may be defined as highly cross linked nano-sized hydrogels ranges from 20-200 nm. They can be administered through various routes, including oral, pulmonary, nasal, parenteral, intra-ocular etc. They have a high degree of drug loading capacity and it shows better permeation capabilities due to smaller size. Nanogels are the novel drug delivery systems for both hydrophilic and hydrophobic drugs.

 

Downloads

Download data is not yet available.

Author Biographies

Saloni Jain, Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India

Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India

Rahul Kumar Ancheria, Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India

Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India

Saumya Shrivastava, Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India

Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India

Shankar Lal Soni, Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India

Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India

Mukesh Sharma, Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India

Department of Pharmaceutics, Arya College of Pharmacy, Kukas, Jaipur, Rajasthan, India

References

1. Alexander V. Kabanov and Serguei V. Vinogradov. Nanogels as Pharmaceutical Carriers, Multifunctional Pharmaceutical Nanocarriers, Springer Science, New York, 2008; 67-80.
2. Dhawal Dorwal Nanogels As Novel And Versatile Pharmaceuticals Inter J Pharm Pharmaceutical Scie, 2012 ;(4):67-74.
3. Kabanov AV1, Vinogradov SV Nanogels as pharmaceutical carriers: finite networks of infinite capabilities. Angew Chem Int Ed Engl 2009; (48):5418-5429.
4. Bencherif SA, Siegwart DJ, Srinivasan A, Horkay F, Hollinger JO, et al. Nanostructured hybrid hydrogels prepared by a combination of atom transfer radical polymerization and free radical polymerization. Biomaterials 2009; (30); 5270–5278.
5. Soni G, Yadav KS Nanogels as potential nanomedicine carrier for treatment of cancer: A mini review of the state of the art. Saudi Pharm J 2006; (24):133-139.
6. Gonçalves C, Pereira P, Gama M Self-Assembled Hydrogel Nanoparticles for Drug Delivery Applications. Materials 2010; (3):1420-1460.
7. Kazakov S, Levon K Liposome-Nanogel Structures for Future Pharmaceutical Applications. Curr Pharm Des 2006; (12):4713-4728.
8. Sultana F, Manirujjaman, Md Imran-Ul-Haque, Arafat M, Sharmin S An Overview of Nanogel Drug Delivery System. J Appl Pharm Sci 2013; (3):95-105.
9. Vinogradov SV Nanogels in the race for drug delivery. Nanomedicine 2010; (5):165–168.
10. Jung Kwon Oh, Ray Drumright, Daniel J. Siegwart, Krzysztof Matyjaszewski, The development of microgels/Nanogels for drug delivery applications, Prog. Polym. Sci. 2008; (33):448–477.
11. Kuroda K, Fujimoto K, Sunamoto J, Akiyoshi K. Hierarchical self-assembly of hydrophobically modified pullulan in water: Gelation by networks of nanoparticles. Langmuir 2002; (18):3780–3786.
12. Lee Y, Park SY, Kim C, Park TG. Thermally triggered intracellular explosion of volume transition Nanogels for necrotic cell death. J. Controlled Release. 2009; 135:89-95.
13. Li Y-Y, Zhang X-Z, Kim G-C, Cheng H, Cheng S-X, Zhuo RX. Thermosensitive Yshaped micelles of poly (oleic acid-Y-Nisopropylacrylamide) for drug delivery. Small 2006; (2):917–923.
14. Singh N, Nisha, Gill V, Gill P Nanogel Based Artificial Chaperone Technology: an Overview.American Journal of Advanced Drug Delivery. American J adva drug del1 2013; 271-276.
15. Lu X, Sun M, Barron AE, Non-ionic thermo-responsive DEA/DMA Nanogels: Synthesis, characterization, and use for DNA separations by microchip electrophoresis. J Colloid Interface Sci 2011; (357):345–353.
16. Fomina N, Sankaranarayanan J, Almutairi A Photochemical mechanisms of light-triggered release from nanocarriers. Adv Drug Deliv Rev 2012; (64):1005–1020.
17. Oh JK, Drumright R, Siegwart DJ, Matyjaszewski K The development of microgels/Nanogels for drug delivery applications. Prog Polym Sci2018; (33):448–477.
18. Tang MD, Golden AP, Tien J Molding of Three-Dimensional Microstructures of Gels. J Am Chem Soc,2013; ( 125):12988-12989.
19. Ferreira SA, Coutinho PJG, Gama FM Synthesis and Characterization of Self-Assembled Nanogels Made of Pullulan. Materials2011; (4)601-620.
20. Alles N, Soysa NS, Hussain MA, Tomomatsu N, Saito H, et al. Polysaccharide Nanogel delivery of a TNF-α and RANKL antagonist peptide allows systemic prevention of bone loss. Euro J Pharm Sci 2009; (37):83-88.
21. Akiyoshi K Nanogel-based Materials for Drug Delivery System. European Cells and Materials 2007; (14):36.
22. Lu A, Moatsou D, Longbottom DA, O’Reilly RK Tuning the catalytic activity of L-proline functionalized hydrophobic Nanogel particles in water. Chem Sci201; (4):965-969.
23. Sanson N, Rieger J Synthesis of Nanogels/microgels by conventional and controlled radical crosslinking copolymerization2010.
24. Park W, Kim KS, Bae B, Kim Y, Na K Cancer cell specific targeting of Nanogels from acetylated hyaluronic acid with low molecular weight. Euro J Pharm Sci 2010; (40):367-375.
25. Wu W, Aiello M, Zhou T, Bernila A, Banerjee P, et al. In situ immobilization of quantum dots in polysaccharide based Nanogel for integreation of optical pH sensing, tumor cell sensing and drug delivery. Biomaterials2010; (31):3023-3031.
26. Wang Q, Xu H, Yang X, Yang Y Drug release behavior from in situ gelatinized thermosensitive Nanogel aqueous dispersions. Int J Pharm2008; 361(90):189-193.
27. Hasegawa U, Nomura ICM, Kaul SC, Hirano T, Akiyoshi K Nanogel quantum dots hybrid nanoparticles for live cell imaging. Biochem Biophys Res Commun 2005; (331):917-921.
28. Look M1, Stern E, Wang QA, DiPlacido LD, Kashgarian M, et al.Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice. J Clin Invest, 2013; 123(9):1741–1749.
29. Shimizu T, Kishida T, Hasegawa U, Ueda Y, Imanishi J, et al.Nanogel DDS enables sustained release of IL-12 for tumor immunotherapy. Biochem Biophys Res Commun2008; (367)330-335.
Bae KH, Mok H, Park TG Synthesis, characterization and intracellular delivery of reducible heparin Nanogels for apoptotic cell death. Biomaterials 2008; (29):3376-3383.

Published

2019-04-15

How to Cite

Jain, S., Ancheria, R. K., Shrivastava, S., Soni, S. L., & Sharma, M. (2019). An Overview of Nanogel –Novel Drug Delivery System. Asian Journal of Pharmaceutical Research and Development, 7(2), 47–55. https://doi.org/10.22270/ajprd.v7i2.482

Most read articles by the same author(s)

1 2 3 > >>