Comparison of In-Vitro Dissolution of Griseofulvin Tablet made from Nano Particles and Solid Dispersion

Authors

  • Nurul Karima Department of Pharmaceutical Technology, Universitas Sumatera Utara, Medan, 20155, North Sumatera, Indonesia
  • Sumaiyah Sumaiyah Department of Pharmaceutical Technology, Universitas Sumatera Utara, Medan, 20155, North Sumatera, Indonesia
  • Azizah Nasution Department of Pharmaceutical Pharmacology, Universitas SumateraUtara, Medan, 20155, North Sumatera, Indonesia

DOI:

https://doi.org/10.22270/ajprd.v8i1.644

Keywords:

dissolution, griseofulvin, nano particle, solid dispersion.

Abstract

Objectives: To find out the comparison of dissolution results of griseofulvin tablets made from nanoparticles, solid dispersions, and conventional materials.

Interventions: Different types of active ingredients in the form of nanoparticles and solid dispersions can affect the dissolution results of tablets.

Main outcomes measure: The results obtained in this study are the cumulative dissolution percentage and the order kinetics of the release of active ingredients.

Conclusion: There was no significant cumulative percent drug release difference (p> 0.05) between nano particles, solid dispersions, and conventional materials. Tablets containing active nanoparticles, solid dispersions, and conventional materials show a linear relationship with a correlation coefficient (R2) close to 1, shown in zero-order kinetics models.

 

 

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Author Biographies

Nurul Karima, Department of Pharmaceutical Technology, Universitas Sumatera Utara, Medan, 20155, North Sumatera, Indonesia

Department of Pharmaceutical Technology, Universitas Sumatera Utara, Medan, 20155, North Sumatera, Indonesia

Sumaiyah Sumaiyah, Department of Pharmaceutical Technology, Universitas Sumatera Utara, Medan, 20155, North Sumatera, Indonesia

Department of Pharmaceutical Technology, Universitas Sumatera Utara, Medan, 20155, North Sumatera, Indonesia

Azizah Nasution, Department of Pharmaceutical Pharmacology, Universitas SumateraUtara, Medan, 20155, North Sumatera, Indonesia

Department of Pharmaceutical Pharmacology, Universitas SumateraUtara, Medan, 20155, North Sumatera, Indonesia

References

1. Lindenberg, M, Kopp S, Dressma JB. Classification of Orally Administered Drugs on The World Health Organization Model List of Essential Medicines According to the Biopharmaceutics Classification System. Eur. J. Pharm. Biopharm. 2004; 58(2):265-278.
2. Kumar, P, Singh, C. A Study on Solubility Enhancement Methods for Poorly Water Soluble Drugs. American Journal of Pharmacological Sciences. 2013; 1(4):67-73.
3. Zaini, E., MD Octavia, KR Wirza. Studi Sistem Dispersi Padat Meloksikam Menggunakan Hidroksipropil Metilselulosa (HPMC) 6 Centipoise (CPS). Jurnal Farmasi Higea. 2017; 4(2):52-73.
4. Sunder, S., Nair R. Methods of Nanonization of Drugs for Enhancing their Dissolution. Eur.J. Adv.Eng.Tech.2016; 3(8):101-110.
5. Wilczewska, AZ, Niemirowicz K, Markiewicz KH, Car H. Nanoparticles as Drug Delivery System. Pharmacological Reports. 2012; 64(5):1020-1037.
6. Junghanns, JUAH, RH Muller. Nanocrystal Technology, Drug Delivery and Clinical Applications. Int J Nanomedicine. 2008; 3(3):295-310.
7. Bhowmik, D, Duraivel GHS, Kumar BP, Raghuvanshi V, Kumar KPS. Solid Dispersion- A Approach To Enhance The Dissolution Rate of Poorly Water Soluble Drugs.The Pharma Innovation-Journal. 2013; 1(12):24-38.
8. Savjani KT, Gajjar AK, Savjani JK. Drug Solubility: importance and enhancement techniques. ISRN Pharm. 20122; 1:1-10.
9. Ramteke, KH, Dighe PA, Kharat AR, Patil SV. Mathematical Models of Drug Dissolution : A Review. Sch. Acad. J. Pharm. 2014; 3(5):388-396.

Published

2020-02-15

How to Cite

Karima, N., Sumaiyah, S., & Nasution, A. (2020). Comparison of In-Vitro Dissolution of Griseofulvin Tablet made from Nano Particles and Solid Dispersion. Asian Journal of Pharmaceutical Research and Development, 8(1), 11–13. https://doi.org/10.22270/ajprd.v8i1.644