Simultaneous Estimation of Admixture drugs by RP-HPLC: A Review
DOI:
https://doi.org/10.22270/ajprd.v8i4.699Keywords:
Analytical methods; chromatographic procedures; drug associations; hyphenated techniques; biologic matrices.Abstract
Recently, high demand of high-throughput analyses with high sensitivity and selectivity to molecules and drugs in different classes with different physical-chemical properties and a reduction in analysis time—is a principal milestone for novel methodologies that researchers are trying to achieve especially when analytical procedures are applied to clinical purposes. In addition, to avoid high doses of a single drug that could cause serious side effects, multi-drug therapies are often used to treat numerous diseases. For these reasons, the demand for methods that allow the rapid analysis of mixed compounds has increased in recent years. In order to respond to these needs, new methods and instruments have been developed. However, often the complexity of a matrix can require a long time for the preparation and processing of the samples. Different problems in terms of components, types of matrices, compounds and physical-chemical complexity are encountered when considering drugs association profiles for quantitative analyses. This review addresses not only recently optimized procedures such as chromatographic separation, but also methods that have allowed us to obtain accuracy (precision and trueness), sensitivity and selectivity in quantitative analyses for cases of drug associations.
Downloads
References
2. T. Bhagyasree, N. Injeti, A. Azhakesan, U.M.V. Rao, A review on analytical method development and validation, International Journal of Pharmaceutical Research & Analysis,2014; (8):444-448.
3. Shrivastava, V.B. Gupta, HPLC: Isocratic or Gradient Elution and Assessment of Linearity in Analytical Methods, J Adv Scient Res, 2012; 3(2):12-20.
4. V. Kumar, R. Bharadwaj, G.G., S. Kumar, An Overview on HPLC Method Development, Optimization and Validation process for drug analysis, The Pharmaceutical and Chemical Journal, 2015; 2(2) 30-40.
5. Validation of Analytical Procedures: Text and Methodology, International Conferences on Harmonization, Draft Revised (2005), Q2 (R1).
6. Validation of Compendial Procedures, United State Pharmacopeia, USP 36 NF, 2010; 27(2).
7. P.K. Singh, M. Pande, L.K. Singh , R.B. Tripathi, steps to be considered during method development and validation for analysis of residual solvents by gas chromatography, Int. Res J Pharm. App Sci., 2013; 3(5):74-80.
8. Prathap, G.H.S. Rao, G. Devdass, A. Dey, N. Harikrishnan , Review on Stability Indicating HPLC Method Development, International Journal of Innovative Pharmaceutical Research.2012; 3(3)229-237.
Published
How to Cite
Issue
Section
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.