Vinpocetine: Hype, Hope and Hurdles towards Neuroprotection

Authors

  • Saurabh C. Vora Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune -411041, Maharashtra, India.
  • Kishor N. Gujar Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune -411041, Maharashtra, India.

Keywords:

Vinpocetine, Neuroprotection, Memory Enhancement, Nootropic, Alzheimer’s Disease, Sundowning Syndrome

Abstract

The in progress research studies and the current knowledge about vinpocetine strongly suggest that “the one molecule fits for many at many times” This review provides a brief overview of vinpocetine for its pharmacokinetics, pharmacodynamics, uses, adverse effects and research summary. In theory, such an ideal “Vinpocetine” preferably known as nootropic is a very effective tool used in memory enhancement. Vinpocetine is a safe and non-toxic with a marvelous range of efficient and structural benefits for superior vigour. However, considering the pharmacokinetic study and uses of Vinpocetine it is a suitable candidate to develop various dosage forms for various disorders. Vinpocetine enhances brain circulation and oxygen consumption by dilating blood vessels and reducing blood stickiness. Vinpocetine is a potent inhibitor of the voltagedependent Na+ channels and a selective inhibitor of the Ca2+/caldmoduline-dependent phosphodiesterasethere. Both vinpocetine and its main metabolite cis-apovincaminic acid exert a neuroprotective type of action. Some hurdles may be produced due to Vinpocetine in the patients associated with Hypotension, Constipation and Seizure.

Downloads

Download data is not yet available.

Published

2013-07-01

How to Cite

Vora, S. C., & Gujar, K. N. (2013). Vinpocetine: Hype, Hope and Hurdles towards Neuroprotection. Asian Journal of Pharmaceutical Research and Development, 1(4), 17–23. Retrieved from https://www.ajprd.com/index.php/journal/article/view/71

Issue

Volume 1st issue 4th July-Aug 2013

Section

Review Articles

AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).