Burn Wound Healing Activity of Ethanolic Extract of Acalypha indica in Oinment Formulated against Rabbits (Ocyctagus caniculus)

Authors

  • Khairani Fitri Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia
  • Tetty Noverita Khairani Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia
  • Fajar Apollo Sinaga Faculty of Sport Science, Universitas Negeri Medan, Medan - Indonesia
  • Amenia Gracia Talunohi Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia

DOI:

https://doi.org/10.22270/ajprd.v8i3.740

Keywords:

Acalypha indica L., ethanolic extract, oinment, wound healing.

Abstract

Objectives: The purpose of this study was to determine burn wound healing activity of Acalypha indica L. in oinment formulated.

Design: This study uses an experimental laboratory design. This study used rabbits as test animals induced by burns with hot iron plates on the back. Extract ointment applied to the wound then observed the development of healing.

Interventions: The extract was formulated in ointments with concentrations of 3, 5 and 7%. positive control used was ointment containing sesame oil and negative control used is an ointment base.

Main outcome measure: The results showed a concentration of 3% had a slow and low effect, at a concentration of 5% it had a moderate healing phase, and a concentration of 7% had a good healing phase.

Conclusion: The ointments containing Acalypha indica leaf extracts have good activity in healing burns in rabbits.

 

 

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Author Biographies

Khairani Fitri, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia

Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia

Tetty Noverita Khairani, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia

Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia

Fajar Apollo Sinaga, Faculty of Sport Science, Universitas Negeri Medan, Medan - Indonesia

Faculty of Sport Science, Universitas Negeri Medan, Medan - Indonesia

Amenia Gracia Talunohi, Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia

Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan- Indonesia

References

Rahman MA, Bachar SC, Rahmatullah M. Analgesic and Antiinflammatory Activity of Methanolic Extract of Acalypha indica Linn. Pak. J. Pharm. Sci. 2010; 23(3):256-258.
2. Zahidin NS, et al. A Review of Acalypha indica L. (Euphorbiaceae) as Traditional Medicine Plant and its Therapeutic Potential. Journal of Ethnopharmacology. 2017; 207:146–173.
3. Venkatachalam P, et al. Accumulation Efficiency, Genotoxicity and Antioxidant Defense Mechanisms in Medicinal Plant Acalypha indica L. under Lead Stress. Chemospher. 2017; 171: 544-553.
4. Nahrstedt A, Hungeling M, Petereit F. Flavonoids from Acalhypa indica. Fitoterapia. 2006; 77: 484–486.
5. Rajsekhar S, Azhar A. Phitochemical Constituents and Pharmacological Activities of Acalyphus indica Linn: A Review. International Jurnal of Pharmaceutical Sciences and Research. 2011; 2(8): 1900-1904.
6. Dineshkumar B, Vigneshkumar P, Bhuvaneshwaran SP, Analava M. Phyto-Pharmacology of Acalypha indica: A Review. IJBSAHM. 2010 ;1(2): 27-32.
7. Higuchi T. Rate of Release of Medicaments from Ointment Bases Containing Drugs in Suspension. Journal of Pharmaceutical Sciences. 1961; 50(10): 874–875.
8. Azwanida NN. A review on the extraction methods use in medicinal plants, principle, strength and limitation. Med Aromat Plants. 2015; 4(196):412–2167.
9. Lemaire C, Plenevaux A, Aerts J, Del Fiore G, Brihaye C, Le Bars D, et al. Solid phase extraction—an alternative to the use of rotary evaporators for solvent removal in the rapid formulation of PET radiopharmaceuticals. J Label Compd Radiopharm Off J Int Isot Soc. 1999; 42(1):63–75.
10. Hafiz I, Rosidah, Silalahi J. Antioxidant and anti-inflammatory activity of pagoda leaves (clerodendrum paniculatum l.) ethanolic extract in white male rats (Rattus novergicus). Int J PharmTech Res. 2016; 9(5):165-170.
11. Suntar I, et al. A novel wound healing ointment: A formulation of Hypericum perforatum oil and sage and oregano essential oils based on traditional Turkish knowledge. Journal of Ethnopharmacology. 2011; 134(1):89–96.
12. Simonsen L, Gert H, Didriksen E, Persson J, Melchior N, Hansen J. Development of a New Formulation Combining Calcipotriol and Betamethasone Dipropionate in an Ointment Vehicle. Drug Development and Industrial Pharmacy. 2004; 10: 1095-1102.
13. Djerrou J, et al. Effect of Virgin Fatty Oil of Pistacia lentiscus on Experimental Burn Wound's Healing in Rabbits. AJOL. 2010; 7(3): 258–263.
14. Ogurtan Z, Hatipoglu F, Ceylan C. The Effect of Alkanna Tictoria Tausch on Burn Wound Healing in Rabbits. Dtsch. tierarztl. Wschr. 2002; 109: 481-485.
15. Anif, M. Ilmu Meracik Obat Teori Dan Praktik. Gadjah Mada University Press. Yogyakarta. 2006.

Published

2020-06-15

How to Cite

Fitri, K., Khairani, T. N., Sinaga, F. A., & Talunohi, A. G. (2020). Burn Wound Healing Activity of Ethanolic Extract of Acalypha indica in Oinment Formulated against Rabbits (Ocyctagus caniculus). Asian Journal of Pharmaceutical Research and Development, 8(3), 18–20. https://doi.org/10.22270/ajprd.v8i3.740