Formulation of Ketoprofen Transdermal Solid Dispersion Patch as an Analgesic and Anti-Inflammatory

Authors

  • Fitri Yani Department of Pharmaceuticals, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
  • Anayanti Arianto Department of Pharmaceuticals, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
  • Rosidah Noersal Department of Pharmaceuticals, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

DOI:

https://doi.org/10.22270/ajprd.v8i3.760

Keywords:

Ketoprofen, Transdermal solid dispersion patch, Analgetic, Anti-inflammatory.

Abstract

Objective: to formulate transdermal patches of ketoprofen solid dispersions, determine the effect of propylene glycol on the rate of release of ketoprofen transdermal solid dispersion patches to know the optimum transdermal patch form of a solid dispersion of ketoprofen could provided better analgesic and antiinflammatory effects compared to the trademark ketoprofen gel (Kaltrofen®).

Design: this research was conducted  using a transdermal experiment of dense solid dispersion patches of ketoprofen with variations in the amount of propylene glycol F1 (10%), F2 (20%) and F3(30%) , physicochemical characteristics (organoleptic, fiber, weight uniformity, folding enhancement and development), diffraction patterns (XRD), incompatibility patterns (FTIR), in vitro penetration testing. -vitro, evaluation of analgesic and anti-inflammatory activity.

Interventions: the intervened  variable were the in vitro penetration testing. In-vitro, evaluation of analgesic and anti-inflammatory effect of ketoprofen transdermal solid dispersion patch.

Main outcome measures: the main measurement in this study were physicochemical characteristics (organoleptic, fiber, weight uniformity, folding enhancement and development), diffraction patterns (XRD), incompatibility patterns (FTIR), in vitro penetration testing. -vitro, evaluation of analgesic and anti-inflammatory activity.

Results: transdermal patches of ketoprofen solid dispersion patches produce white, odorless preparations that have a flat surface, thickness between 0.0242 ± 0.0002 to 0.0269 ± 0.0003, weight uniformity 321.50 ± 0.78 to 381.54 ± 0.60, folding resistance between 375 ± 0.58 to 443 ± 1.53, all formulas already meet the requirements of physicochemical characteristics. F3 ketoprofen transdermal solid dispersion patch had a highest penetration degree and provide better analgesic effects compared to the trademark ketoprofen gel (Kaltrofen®), and there were significant differences between groups (p>0.05).

Conclusion: it can be concluded that the use of 30% propylene glycol in F3 ketoprofen transdermal solid dispersion patch affects the rate of drug release and  had a better anti-inflammatory effect compared to the trademark ketoprofen gel (Kaltrofen®).

 

 

Downloads

Download data is not yet available.

Author Biographies

Fitri Yani, Department of Pharmaceuticals, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Department of Pharmaceuticals, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Anayanti Arianto, Department of Pharmaceuticals, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Department of Pharmaceuticals, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Rosidah Noersal, Department of Pharmaceuticals, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Department of Pharmaceuticals, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

References

1. Adachi, Ioppolo L., Paoloni K., dan Santilli. Physical Characteristics, Pharmacological Properties and Clinical Efficacy of the Ketoprofen Patch: A New Patch Formulation. Eur Rev Med Phar Sci. 2011; 15: 823-830.
2. Vueba, J., Carvalho, V., Veiga, S.J., Sousa, R., dan Pina, S. Influence of Cellulose Ether Polymers on Ketoprofen Release from Hydrophilic Matrix Tablets. Internatioanal Journal of Pharmaceutical. 2004: 58: 51-59.
3. Shinkai, Korenaga, Mizu, dan Yamauchi. Intra-Articular Penetration of Ketoprofen and Analgesic Effects After Topical Patch Application in Rats. Journal Control Release. 2008; 131: 107-112.
4. Williams, A.C., dan Barry, B.W. Penetration Enhancers. Advanced Drug Delivery Reviews. 2004; 56: 603-618.
5. Ammar, H.O., M. Ghorabb, S. A., El-Nahhasa., dan Kamela, R. Evaluation of Chemical Penetration Enhancer for Transdermal Delivery of Aspirin. Asian Journal of Pharmaceutical sciences. 2007; 2 (3): 96-105.
6. Sharma, K., Mittal, A., dan Agrahari, P. Skin Permeation of Candesartan Cilexetil from Transdermal Patch Containing Aloe Vera Gel as Penetration Enhancer. Asian Journal of Pharmaceutics. 2013; 10 (2): 124.
7. Okyar, A., Ozsoy, Y., dan Gungor. Novel Formulation Approaches for Dermal and Transdermal Delivery of Non-Steroidal Anti-Inflamatory Drugs, Rhematoid Arthritis-Treatment. Europe: In Tech Europe. 2013. p. 102-106.
8. Venkatraman, S.N., Davar, A., Chester, dan Kleiner, L. An Overview of Controlled Release System. Handbook of Pharmaceutical Controlled Release Technology. New York: Marcell Dekker, Inc. 2002. p.48-60.
9. Prabhakar, D.J., Sreekanth, dan Jayaveera, K.N. Transdermal Drug Delivery Patch: A Review. Journal of Drug Delivery and Therapeutics. 2013; 3 (4): 213-221.
10. Nurahmanto, D., Sabrina, F.W., dan Ameliana, L. Optimasi Polivinilpirolidon dan Carbopol Pada Sediaan Patch Dispersi Padat Piroksikam. Skripsi. Fakultas Farmasi Universitas Jember. 2017. p. 27.
11. Wen, H., dan Park, K.. Oral controlled release formulation design and drug delivery. Theory to practice. New Jersey: John Wiley & Sons, Inc. 2010. p.113.
12. Bharkatiya, M.R.K., Nema, M., dan Bhatnagar. Development and Characterization of Transdermal Patches of Metoprolol Tartrate. Asian Journal of Pharmaceutical and Clinical Research. 2010; 3 (2): 130-134.
13. Kandavili, S., Nair, V., dan Panchagnula, R. Polymers in Transdermal Drug Delivery Systems. Pharmaceutical Technology and Research. 2002; 62-80.
14. Sweetman, S.C. Martindale: The Complete Drug Refrence. Thirty-sixth Edition. London: Pharmaceutical Press. 2009. p.782-811.
15. Bhowmik, D., Duraivel, G.H.S., Kumar, B.P., Raghuvanshi, V., dan Kumar., K.P. S. Solid Dispersion-A Approach To Enhance The Dissolution Rate of Poorly Water Soluble Drugs.The Pharma Innovation-Journal. 2013; 1 (12): 24-38.
16. Zakir, S., Banu, S.K., Fatima, S.N., Jahan, T., Firdous, W., Sireesha, Roshan, S., dan Mahammed, N.L. Formulation and Evaluation of Transdermal Patchs of Ketoprofen by Using Different Polymers. International Journal Pharmaceutical Science. 2015; 3 (4): 989-996.
17. Newa, M., Bhandari, K.H., Kim, O.J., Im, S.J., Kim, J.A., dan Yoo, B.K. Preparation and Evaluation of Immediate Release Ibuprofen Solid Dispersion Using Polyethylene Glycol 4000. Biol.Pharm.Bull. 2008; 31 (5): 939-945.
18. Akhtar, N., Rehman, M.U., Khan, H.M.S., Rasool, F., Saeed, T., dan Murtaza, G. Penetration Enhancing Effect of Polysorbate 20 and 80 on the In Vitro Percutaneous Absorption of L-Ascorbic Acid. Tropical Journal of Pharmaceutical Research. 2011; 10 (3): 281-288.
19. Ramkanth, S., Jayaprakash, S., dan Vimalakanan, T. Formulation and Evaluation of A Monolithic drug-In-Adhesive Type Patch Containing Tenoxicam. International Journal of Pharma Sciences and Research (IJPSR). 2015; 6 (4): 9475-9492.
20. Tyagi, S., dan Goyal, K.. Transdermal Drug Delivery System: Quality Approaches And Evaluation. Innovat International Journal Of Medical & Pharmaceutical Sciences. 2017; 2 (3): 15-21.
21. Rowe, R.C., Sheskey, P.J., dan Quinn, M.E.. Handbook of Pharmaceutical Exipients. Edisi keenam. London: Pharmaceutical Press and American Pharmacists Assosiation. 2009. p. 257, 273, 413.
22. Jhawat, C.V., Saini, S. Kamboj, dan Maggon, N. Transdermal Drug Delivery System: Approaches and Advancements in Drug Absorption Through Skin. International Journal of Pharmaceutical Sciences and Research. 2013; 47-56.
23. Chandra, Ramesh, Vamshi, Kishan, dan Madhsudan. Development of Mucoadhesive Patches for Buccal Administration of Prochlorperazine: Evaluation of In Vitro Release and Mechanical Properties. International Journal of Pharmaceutical Sciences and Nanotechnology. 2008; 1: 64-70.
24. Zaini, E., Sumirtapura, Y. C., Soewandhi, S. N., dan Halim, A. Identifikasi Interaksi Fisika antara Trimetoprim dan Sulfametoksazole dengan Metode Kontak Kofler dan reaksi kristalisasi. Majalah Farmasi Indonesia. 2010; 21(1):32-39.
25. Benson, H.A.E., dan Watkinson, A.C. Topical and Transdermal Drug Delivery: Principles and Practice. A John Wiley & Sons inc. Publication. 2012. p. 85-89.
26. Chauhan, S., Bolmal, U.D., Dandagi, P.M., dan Singh, A. Design and Evaluation of Transdermal Patch of Felodipine. Indo American Journal of Pharmaceutical Research. 2015; 5(09): 2231-6876.
27. Kumar, S., Tarun, P., dan Kumar, T. Transdermal Drug Delivery System for Non-Steroidal Anti-Imflammatory Drug: A Review. Journal of Control Release. 2013; 3588-3605.
28. Anwar, K., Santoso, H.B., dan Cahaya, N. (2013). Penghambatan Radang Infusa Daun Dadap Ayam (Erythrina variegata L.) Pada Mencit Jantan yang di induksi Karagenin. Prosiding Semirata FMIPA Universitas Lampung. 2013. p.73.

Published

2020-06-15

How to Cite

Yani, F., Arianto, A., & Noersal, R. (2020). Formulation of Ketoprofen Transdermal Solid Dispersion Patch as an Analgesic and Anti-Inflammatory. Asian Journal of Pharmaceutical Research and Development, 8(3), 51–58. https://doi.org/10.22270/ajprd.v8i3.760