Sustained Release Matrix Tablet: An Overview
DOI:
https://doi.org/10.22270/ajprd.v9i3.954Keywords:
Sustained release, Mechanism of drug release, Matrix tablet, Drug propertiesAbstract
Sustained Release is also a promising method for reducing medication side effects by preventing the therapeutic concentration of the drug from fluctuating in the body.The basic rationale of a sustained drug delivery system is to optimise a drug's biopharmaceutical, pharmacokinetic, and pharmacodynamic properties in order to maximise utility, minimise side effects, and cure the disease. The drug release rate is regulated by the matrix. HPMC and other release retardants can help with sustained release, so they are used as a key excipient in the formulation.The method entails compressing a mixture of medication, retardant material, and additives directly to shape a tablet with the drug embedded in a retardant matrix core; instead, granulation may be done prior to compression. Hydrophilic, hydrophobic, mineral, and biodegradable matrices may be used.To assess the drug release rate, in-vitro dissolution tests may be used. The primary goal of continuous release types is to improve drug therapy, which is determined by the relationship between the advantages and disadvantages of using one.
Downloads
References
2. Rao N. G. R, Raj K. R, P, Nayak B. S. Review on matrix tablet as sustained Release. Int J Pharm Res All Sci. (2013); 2(3):1-17.
3. Agarwal G,Agarwal S, Karar P.K, Goyal S. Oral sustained release tablets: An Overview with a Special Emphasis on matrix tablet. Ame J Adv Drug Deliv. 2017;5(2):64-76.
4. Alli P.R, PratimaB. Bargaje, Nilesh S. Mhaske. Sustained selease drug delivery system: A Modern Formulation Approach. Asian J Pharm Tech Innov. 2016;4(17): 108 –18.
5. Lokhande S.S, Phalke N. N, Badadare S. S. A review On: Sustained release technology. World J Pharma Med Res.2019;5(11):60-65
6. Zalte H.D, Saudagar R.B. Review on sustained release matrix tablet. Int JPharm Bio Sci.2013;3(4):17-29
7. Gupta M.M., Ray B. A review On: Sustained release technology. Int J of Thera Appl.2012;8:18 – 23.
8. Mandhar P, Joshi G. Development ofsustained release drug delivery system: A review. Asian Pac. J. Health Sci., 2015; 2(1):179-85.
9. Kambampati S, J. N. Suresh Kumar., C.H Sriram. A Review on Sustained Release Drug Delivery System.Int J Res Pharma and Nano Sci. 2013; 2(4):441 - 47.
10. Bose s, Kaur A, Sharma S. K. A review on advances of sustained release drug delivery system. Int J Res Pharm.2013;4(6):1-5.
11. Patel N, Chaudhary A, Twinkle S, MehulS, Jain H , Upadhyay U. Controlled drug delivery system: A review. Indo Ame JPharm Sci. 2016;3(3):227-33.
12. Pareek S P, Kumawat S , Sharma V, Sharma D , Rathore D. S , Agarwal M. Review on sustained release technology. Int J Pharm Bio Sci Archive. 2019;7(6): 29-38.
13. Patel H, Dhrupesh R. Panchal, Patel U, Brahmbhatt T, Sutha M. Matrix type drug delivery system: A Review. JPharm Sci Bio Res. 2011;1(3):143-51.
14. Kumar A.R, Aeila A.S.S. Sustained release matrix type drug delivery system: An overview. World J Pharm Pharm Sci,2019;8(12):470-80.
Published
How to Cite
Issue
Section
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).