Recent Update on Topical Drug Delivery Systems: Emulgel
DOI:
https://doi.org/10.22270/ajprd.v11i4.1299Keywords:
Emulsion , Topical Emulgel , gelling agent, Emulsifier, Thixotropic , Cosmetics.Abstract
Emulgel is an emerging topical drug delivery system that, if more effort is devoted to its formulation and development with more topically active drugs, will prove to be a boon to skin care and cosmetology. Emulgels are both O/W or W/O emulsions which might be gelled with the aid of mixing with a gelling agent. Incorporating the emulgel increases its stability and makes it controlled release system. Due to the lack of excess oil bases and insoluble excipients, it exhibits better drug release compared to other topical drug delivery systems. The presence of the gel phase makes it non-greasy and promotes good affected person cooperation. Those reviews provide knowledge approximately Emulgel such as its properties, benefits, formulations and its current research advances. All elements consisting of the choice of gelling agent, oil agent, emulsifiers affecting the stability and effectiveness of Emulgel are discussed. All rationales are defined in accordance with study conducted via numerous scientists. After anin depth examine, it could be concluded that Emulgels appear to be a better and greater effective drug delivery system compared to other topical drug delivery systems. A complete analysis of the rheological and release properties will offer insight into the capacity use of the Emulgel formulation as a drug delivery System.
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References
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4. Rosen H, Abribat T. The rise and rise of drug delivery. Nature Reviews Drug Discovery. 2005 May; 4(5):381-5.
5. Zi P, Yang X, Kuang H, Yang Y, Yu L. Effect of HPβCD on solubility and transdermal delivery of capsaicin through rat skin. International journal of pharmaceutics. 2008 Jun 24;358(1-2):151-8.
6. Shokri J, Azarmi S, Fasihi Z, Hallaj-Nezhadi S, Nokhodchi A, Javadzadeh Y. Effects of various penetration enhancers on percutaneous absorption of piroxicam from emulgels. Research in Pharmaceutical Sciences. 2012 Oct; 7(4):225.
7. Foldvari M. Non-invasive administration of drugs through the skin: challenges in delivery system design. Pharmaceutical science & technology today. 2000 Dec 1; 3(12):417-25.
8. Elsayed MM, Abdallah OY, Naggar VF, Khalafallah NM. Lipid vesicles for skin delivery of drugs: reviewing three decades of research. International journal of pharmaceutics. 2007 Mar 6; 332(1-2):1-6.
9. Mohamed MI. Optimization of chlorphenesinemulgel formulation. The AAPS journal. 2004 Sep;6(3):81-7.
10. Dobrovolskaia MA. Understanding nanoparticle immunotoxicity to develop safe medical devices. The immune response to implanted materials and devices. 2017:63-80.
11. Alexander A, Dwivedi S, Giri TK, Saraf S, Saraf S, Tripathi DK. Approaches for breaking the barriers of drug permeation through transdermal drug delivery. Journal of Controlled Release. 2012 Nov 28; 164(1):26-40.
12. Jain, P. Deveda, N. Vyas, J. Chauhan, Development of antifungal emulsion based gel for topical fungal infection, IJPRD 2 (2011) 18–25.
13. Panwar A, Upadhyay N, Bairagi M, Gujar S, Darwhekar G, Jain D. Emulgel: a review. Asian J Pharm Life Sci. 2011; 2231:4423.
14. Sarisozen C, Vural I, Levchenko T, Hincal AA, Torchilin VP. PEG-PE-based micelles co-loaded with paclitaxel and cyclosporine A or loaded with paclitaxel and targeted by anticancer antibody overcome drug resistance in cancer cells. Drug Delivery. 2012 May 1;19(4):169-76.
15. A.A.Kale,V.P. Torchilin, “Smart” drug carriers: PEGylatedTATp-modified pH-sensitive liposomes, J. Liposome Res. 17 (2007) 197–203.
16. O.E. Philippova, A.R. Khokhlov, 1.13-polymer gels, in: Editors-in-Chief: M. Krzysztof, M. Martin (Eds.) Polymer Science: A Comprehensive Reference,
Elsevier, Amsterdam, 2012, pp. 339–366.
17. Dickinson E. Hydrocolloids as emulsifiers and emulsion stabilizers. Food hydrocolloids. 2009 Aug 1;23(6):1473-82.
18. Ajazuddin, Alexander A, Khan J, Giri TK, Tripathi DK, Saraf S, Saraf S. Advancement in stimuli triggered in situ gelling delivery for local and systemic route. Expert opinion on drug delivery. 2012 Dec 1;9(12):1573-92.
19. Raut S, Uplanchiwar V, Bhadoria S, Gahane A, Jain SK, Patil S. Comparative evaluation of zidovudine loaded hydrogels and emulgels. Res J Pharm Technol. 2012 Jan 28;5:41
20. Caddeo C, Sales OD, Valenti D, Saurí AR, Fadda AM, Manconi M. Inhibition of skin inflammation in mice by diclofenac in vesicular carriers: liposomes, ethosomes and PEVs. International journal of pharmaceutics. 2013 Feb 25;443(1-2):128-36.
21. Rahmani‐Neishaboor E, Jallili R, Hartwell R, Leung V, Carr N, Ghahary A. Topical application of a film‐forming emulgel dressing that controls the release of stratifin and acetylsalicylic acid and improves/prevents hypertrophic scarring. Wound Repair and Regeneration. 2013 Jan;21(1):55-65.
22. J. Khan, A. Alexander, Ajazuddin, S. Saraf, S. Saraf, Recent advances and future prospects of phyto-phospholipid complexation technique for improving phar-macokinetic profile of plant actives, J. Control. Release.
23. Rahmani‐Neishaboor E, Jallili R, Hartwell R, Leung V, Carr N, Ghahary A. Topical application of a film‐forming emulgel dressing that controls the release of stratifin and acetylsalicylic acid and improves/prevents hypertrophic scarring. Wound Repair and Regeneration. 2013 Jan; 21(1):55-65.
24. K. Bowey, J.F. Tanguay, M. Tabrizian, Liposome technology for cardiovascular disease treatment and diagnosis, Expert Opin. Drug Deliv. 9 (2012) 249–265.
25. Sawant RR, Torchilin VP. Multifunctionality of lipid-core micelles for drug delivery and tumour targeting. Molecular membrane biology. 2010 Oct 1; 27(7):232-46.
26. Habashy RR, Abdel-Naim AB, Khalifa AE, Al-Azizi MM. Anti-inflammatory effects of jojoba liquid wax in experimental models. Pharmacological research. 2005 Feb 1; 51(2):95-105.
27. Jain A, Deveda P, Vyas N, Chauhan J, Khambete H, Jain S. Development of antifungal emulsion based gel for topical fungal infection (s). IJPRD. 2011; 2(12):18-22.
28. Deveda P, Jain A, Vyas N, Khambete H, Jain S. Gellified emulsion for sustain delivery of itraconazole for topical fungal diseases. International Journal of Pharmacy and Pharmaceutical Sciences. 2010; 2(1):104-12.
29. Bhanu PV, Shanmugam V, Lakshmi PK. Antimicrobial preservative activity of the formulated diclofenacemulgel, a novel drug delivery for topical use. The Pharma Professionals. 2011;1(1):5-10.
30. Shrikhande PV. Formulation and evaluation of polyherbal topical anti-inflammatory emulgel. Research journal of pharmacy and technology. 2013; 6(1):11.
31. Behera B, Biswal D, Uvanesh K, Srivastava AK, Bhattacharya MK, Paramanik K, Pal K. Modulating the properties of sunflower oil based novel emulgels using castor oil fatty acid ester: Prospects for topical antimicrobial drug delivery. Colloids and Surfaces B: Biointerfaces. 2015 Apr 1; 128:155-64.
32. Chen XW, Fu SY, Hou JJ, Guo J, Wang JM, Yang XQ. Zein based oil-in-glycerol emulgels enriched with β-carotene as margarine alternatives. Food chemistry. 2016 Nov 15;211:836-44.
33. Leon-Méndez G, Osorio-Fortich M, Ortega-Toro R, Pajaro-Castro N, Torrenegra-Alarcón M, Herrera-Barros A. Design of an emulgel-type cosmetic with antioxidant activity using active essential oil microcapsules of thyme (Thymus vulgaris L.), Cinnamon (Cinnamomumverum J.), and clove (Eugenia caryophyllata T.). International Journal of Polymer Science. 2018 Jan 1; 2018.
34. Mohite S, Salunkhe A. Formulation and evaluation of Emulgel containing Coriandrumsativum seeds oil for Anti-inflammatory activity. Journal of Drug Delivery and Therapeutics. 2019 Jun 15;9(3-s):124-30.
35. Nasirpour-Tabrizi P, Azadmard-Damirchi S, Hesari J, Heshmati MK, Savage GP. Rheological and physicochemical properties of novel low-fat emulgels containing flaxseed oil as a rich source of ω-3 fatty acids. LWT. 2020 Nov 1; 133:110107.
36. Rawooth M, Qureshi D, Hoque M, Prasad MG, Mohanty B, Alam MA, Anis A, Sarkar P, Pal K. Synthesis and characterization of novel tamarind gum and rice bran oil-based emulgels for the ocular delivery of antibiotics. International Journal of Biological Macromolecules. 2020 Dec 1;164:1608-20.
37. Maïssa C, Guillon M, Simmons P, Vehige J. Effect of castor oil emulsion eyedrops on tear film composition and stability. Contact Lens and Anterior Eye. 2010 Apr 1;33(2):76-82.
38. Zhu K, Zhou H, Qian H. Antioxidant and free radical-scavenging activities of wheat germ protein hydrolysates (WGPH) prepared with alcalase. Process Biochemistry. 2006 Jun 1;41(6):1296-302.
39. Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Advanced drug delivery reviews. 2000 Dec 6;45(1):89-121.
40. Di Mattia CD, Sacchetti G, Mastrocola D, Pittia P. Effect of phenolic antioxidants on the dispersion state and chemical stability of olive oil O/W emulsions. Food research international. 2009 Oct 1;42(8):1163-70.
41. Lupi FR, Gabriele D, Facciolo D, Baldino N, Seta L, De Cindio B. Effect of organogelator and fat source on rheological properties of olive oil-based organogels. Food Research International. 2012 Apr 1;46(1):177-84.
42. Hartman C, Ben-Artzi E, Berkowitz D, Elhasid R, Lajterer N, Postovski S, Hadad S, Shamir R. Olive oil-based intravenous lipid emulsion in pediatric patients undergoing bone marrow transplantation: a short-term prospective controlled trial. Clinical Nutrition. 2009 Dec 1;28(6):631-5.
43. Jäger S, Laszczyk MN, Scheffler A. A preliminary pharmacokinetic study of betulin, the main pentacyclictriterpene from extract of outer bark of birch (Betulaealba cortex). Molecules. 2008 Dec 18;13(12):3224-35.
44. Pires C, Ramos C, Teixeira G, Batista I, Mendes R, Nunes L, Marques A. Characterization of biodegradable films prepared with hake proteins and thyme oil. Journal of Food Engineering. 2011 Aug 1;105(3):422-8.
45. Ziani K, Chang Y, McLandsborough L, McClements DJ. Influence of surfactant charge on antimicrobial efficacy of surfactant-stabilized thyme oil nanoemulsions. Journal of agricultural and food chemistry. 2011 Jun 8;59(11):6247-55.
46. Lee SJ, Umano K, Shibamoto T, Lee KG. Identification of volatile components in basil (Ocimumbasilicum L.) and thyme leaves (Thymus vulgaris L.) and their antioxidant properties. Food Chemistry. 2005 Jun 1;91(1):131-7.
47. Fei Lu, Ding Yc, Ye Xq, Ding Yt. Antibacterial effect of cinnamon oil combined with thyme or clove oil. Agricultural Sciences in China. 2011 Sep 1;10(9):1482-7.
48. Karabacak M, Kanbur M, Eraslan G, Sarıca ZS. The antioxidant effect of wheat germ oil on subchroniccoumaphos exposure in mice. Ecotoxicology and environmental safety. 2011 Oct 1;74(7):2119-25.
49. Małecka M. Antioxidant properties of the unsaponifiable matter isolated from tomato seeds, oat grains and wheat germ oil. Food Chemistry. 2002 Nov 1;79(3):327-30.
50. Jing F, An X, Shen W. The characteristics of hydrolysis of trioleincatalyzed by wheat germ lipase in water-in-oil microemulsions. Journal of Molecular Catalysis B: Enzymatic. 2003 Oct 1;24:53-60.
51. Tipton DA, Lyle B, Babich H, Dabbous MK. In vitro cytotoxic and anti-inflammatory effects of myrrh oil on human gingival fibroblasts and epithelial cells. Toxicology in vitro. 2003 Jun 1;17(3):301-10.
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Published
2023-08-13
How to Cite
Lilhare, K. T., Borkar, S. S., & R. Baheti, J. (2023). Recent Update on Topical Drug Delivery Systems: Emulgel. Asian Journal of Pharmaceutical Research and Development, 11(4), 133–138. https://doi.org/10.22270/ajprd.v11i4.1299
Issue
Section
Review Articles
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