New Insights in Topical Drug Delivery for Skin Disorders: A Review
DOI:
https://doi.org/10.22270/ajprd.v12i2.1323Abstract
Drug delivery systems are methods which are used to ensure that drugs get into the body and reach the area where they are needed. These systems must take a number of needs into account, ranging from ease of delivery to effectiveness of the drugs. The paper reviews an overview of a conventional and novel approach in the topical drug delivery system. Drug delivery via the skin is becoming progressively popular due to its convenience and affordability. The skin is the most important mechanical barrier to the penetration of many drug substances and acts as an ideal site to deliver the drug both locally and systemically. The topical route has been a favored route of drug administration over the last decades. Despite conventional topical drug delivery systems limits in poor retention and low bioavailability. To address some of the limitations posed by conventional dermatotherapy, nano-based technologies have been developed and have demonstrated a significant improvement in dermatotherapy. Their distinct physicochemical properties demonstrate their overall superior therapeutic efficacy in providing sustained and effective targeted drug release, as well as improved solubility of hydrophobic actives with optimized drug formulations. These nanocarriers are commonly classified as polymeric, lipid-based, metallic, and vesicular nanocarriers, including nanoemulsions, nanofibers, and microneedles.
Downloads
References
Wang M, Luo Y, Wang T, Wan C, Pan L, Pan S, et al. Artificial skin perception.Adv Mater. 2020; 33:e2003014.
Hutton AR, McCrudden MT, Larrañeta E, Donnelly RF. Influence of molecularweight on transdermal delivery of model macromolecules using hydrogel-forming microneedles: potential to enhance the administration of novel lowmolecular weight biotherapeutics. J Mater Chem B. 2020;8(19]:4202–9.https://doi.org/10.1039/D0TB00021C.
Andrews SM, Jeong EH, Prausnitz MR. Transdermal delivery of molecules is limited by full epidermis, Not Just Stratum Corneum. Pharm Res. 2013; 30(4]:1099–109.
Chaulagain B, Jain A, Tiwari A, Verma A, Jain SK. Passive delivery of protein drugs through transdermal route. Artif Cells NanomedBiotechnol. 2018; 46(1]:472–87. https://doi.org/10.1080/21691401.2018.1430695.
Schuetz, Y.B.; Naik, A.; Guy, R.H.; Kalia, Y.N. Emerging Strategies for the Transdermal Delivery of Peptide and Protein Drugs. Expert Opin. Drug Deliv. 2005, 2, 533–548.
Schoellhammer, C.M.; Blankschtein, D.; Langer, R. Skin Permeabilization for Transdermal Drug Delivery: Recent Advances and Future Prospects. Expert Opin. Drug Deliv. 2014, 11, 393–407.
Shahzad, Y.; Louw, R.; Gerber, M.; du Plessis, J. Breaching the Skin Barrier through Temperature Modulations. J. Control. Release 2015, 202, 1–13.
Hopp SM. Developing Custom Adhesive Systems forTransdermal Drug Delivery Products. Pharmaceutical Technology 2002, 30-36.
Misra AN. Transdermal Drug Delivery. In Jain NK, Editor. Controlled and Novel Drug Delivery. New Delhi: CBS Publishers and Distributors, 2002; 101-107.
Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotech-nol. 2008; 26(11]:1261–8.
Kalia YN, Merino V, Guy RH. Transdermal drug delivery: clinical aspects. Dermatol Clin. 1998; 16(2]:289–99.
Kornick CA, Santiago-Palma J, Moryl N, Payne R, Obbens EA. Beneft-risk assessment of transdermal fentanyl for the treatment of chronic pain. Drug Saf. 2003;26(13]:951–73.
Ita K. Transdermal delivery of drugs with microneedles—potential and challenges. Pharmaceutics. 2015;7(3]:90–105.
Varvel J, Shafer S, Hwang S, Coen P, Stanski D. Absorption characteristics of transdermally administered fentanyl. The Journal of the American Society of Anesthesiologists. 1989;70(6]:928–34.
Rouphael NG, Paine M, Mosley R, Henry S, McAllister DV, Kalluri H, et al. The safety, immunogenicity, and acceptability of inactivated infuenza vaccine delivered by microneedle
patch [TIV-MNP 2015]: a randomised, partly blinded, placebo-controlled, phase 1 trial. Lancet. 2017; 390(10095]:649–https://doi.org/10.1016/s0140-6736 (17]30575-5.
Kim E, Erdos G, Huang S, Kenniston TW, Balmert SC, Carey CD, et al. Microneedle array delivered recombinant coronavirus vaccines: immunogenicity and rapid translational development. EBioMedicine. 2020; 55:102743.
Liu GS, Kong Y, Wang Y, Luo Y, Fan X, Xie X, et al. Microneedles for transdermal diagnostics: recent advances and new horizons. Biomaterials. 2020;232:119740.
Yarmush, M.L.; Golberg, A.; Sersa, G.; Kotnik, T.; Miklavcic, D. Electroporation-based technologies for medicine: Principles,applications, and challenges. Annu. Rev. Biomed. Eng. 2014, 16, 295–320.
Eriksson, F.; Totterman, T.; Maltais, A.-K.; Pisa, P.; Yachnin, J. DNA vaccine coding for the rhesus prostate specific antigendelivered by intradermal electroporation in patients with relapsed prostate cancer. Vaccine 2013, 31, 3843–3848.
Thomson, K.R.; Cheung, W.; Ellis, S.J.; Federman, D.; Kavnoudias, H.; Loader-Oliver, D.; Roberts, S.; Evans, P.; Ball, C.; Haydon, A.Investigation of the Safety of Irreversible Electroporation in Humans. J. Vasc. Interv. Radiol. 2011, 22, 611–621.
Sammeta, S.M.; Vaka, S.R.K.; Murthy, S.N. Transcutaneous electroporation mediated delivery of doxepin-HPCD complex: Asustained release approach for treatment of postherpetic neuralgia. J. Control. Release 2010, 142, 361–367.
Singer, A.J.; Homan, C.S.; Church, A.L.; McClain, S.A. Low‐frequency Sonophoresis: Pathologic and Thermal Effects in Dogs. Acad. Emerg. Med. 1998, 5, 35–40.
Waghule, T.; Singhvi, G.; Dubey, S.K.; Pandey, M.M.; Gupta, G.; Singh, M.; Dua, K. Microneedles: A smart approach andincreasing potential for transdermal drug delivery system. Biomed. Pharmacotherapy 2019, 109, 1249–1258.
Ita, K. Transdermal Delivery of Drugs with Microneedles-Potential and Challenges. Pharmaceutics 2015, 7, 90–105.
Whitley RJ, Roizman B. Herpes simplex virus infections. Thelancet. 2001;357(9267]:1513–8.
Saxena A, Tewari G, Saraf SA. Formulation and evaluation ofmucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon. Braz J Pharm Sci. 2011;47(4]:887–97.
Shojaei AH, Zhuo S, Li X. Transbuccal delivery of acyclovir [II]:feasibility, system design, and in vitro permeation studies. J Pharm Sci. 1998; 1(2]:66–73.
Rossi S, Sandri G, Ferrari F, Bonferoni MC, Caramella C. Buccaldelivery of acyclovir from flms based on chitosan and polyacrylic acid. Pharm Dev Technol. 2003; 8(2]:199–208.
Schoellhammer, C.M.; Blankschtein, D.; Langer, R. Skin Permeabilization for Transdermal Drug Delivery: Recent Advances and Future Prospects. Expert Opin. Drug Deliv. 2014, 11, 393–407.
Gratieri, T.; Alberti, I.; Lapteva, M.; Kalia, Y.N. Next Generation Intra-and Transdermal
Therapeutic Systems: Using Non-and Minimally-Invasive Technologies to Increase DrugDelivery into and Across the Skin. Eur. J. Pharm. Sci. 2013, 50, 609–622.
Lakshmanan, S.; Gupta, G.K.; Avci, P.; Chandran, R.; Sadasivam, M.; Jorge, A.E.S.; Hamblin, M.R. Physical Energy for Drug Delivery; Poration, Concentration and Activation. Adv. Drug Deliv. Rev. 2014, 71, 98–114.
Badkar, A.V.; Banga, A.K. Electrically Enhanced Transdermal Delivery of a Macromolecule. J. Pharm. Pharmacol. 2002, 54, 907–912.
Published
Versions
- 2024-04-20 (2)
- 2024-04-15 (1)
How to Cite
Issue
Section
Copyright (c) 2024 Madhurima Saini, Dr. Shiv Garg, Dr. Piush Sharma, Dr. Shailendra bhatt
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.