A Concise Review on Contemporary and Novel Treatments Addressing the Prevention and Control of Hyperpigmentation
DOI:
https://doi.org/10.22270/ajprd.v12i2.1363Abstract
Hyperpigmentation is a common skin condition characterized by the darkening of certain areas of the skin due to an excess production of melanin. This condition can be caused by a variety of factors, including sun exposure, hormonal changes, inflammation, and skin injuries. Hyperpigmentation can have a significant impact on a person's self-esteem and quality of life. Hormonal changes, such as those experienced during pregnancy or menopause, can also lead to hyperpigmentation. Inflammation from conditions like acne or eczema can cause the skin to produce excess melanin, resulting in dark spots or patches. Additionally, skin injuries, such as cuts or burns, can trigger the body to produce more melanin as part of the healing process, leading to hyperpigmentation. Creams containing ingredients like hydroquinone, retinol, or vitamin C can help lighten dark spots and even out skin tone. Medications containing corticosteroids, may be recommended for more severe cases of hyperpigmentation. In addition, novel drug delivery systems such as liposomes, Transferosomes, Niosomes etc. have shown better penetration topically hence they can be used to treat pigmentation. Understanding the causes of hyperpigmentation and seeking appropriate treatment can help improve the overall health and appearance of the skin. By addressing the underlying factors contributing to hyperpigmentation and using targeted skincare products or treatments, individuals can achieve a more even complexion and feel more confident in their skin.
Background: The topic of hyperpigmentation is of significant interest in dermatology and cosmetology due to its widespread prevalence and impact on individuals' skin health and appearance.several traditional treatments such as topical hydroquinone and retinoids have been utilized for managing hyperpigmentation, there is an increasing recognition of the need for more effective and targeted intervention.
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Lee AY. Skin Pigmentation Abnormalities and Their Possible Relationship with Skin Aging. Int J Mol Sci. 2021 Apr 2;22(7):3727. doi: 10.3390/ijms22073727. PMID: 33918445; PMCID: PMC8038212.
Videira IF, Moura DF, Magina S. Mechanisms regulating melanogenesis. Anais brasileiros de dermatologia. 2013;88:76-83.
Martin AR, Lin M, Granka JM, Myrick JW, Liu X, Sockell A, Atkinson EG, Werely CJ, Möller M, Sandhu MS, Kingsley DM. An unexpectedly complex architecture for skin pigmentation in Africans. Cell. 2017 Nov 30;171(6):1340-53.
Thawabteh AM, Jibreen A, Karaman D, Thawabteh A, Karaman R. Skin Pigmentation Types, Causes and Treatment-A Review. Molecules. 2023 Jun 18;28(12):4839. doi: 10.3390/molecules28124839. PMID: 37375394; PMCID: PMC10304091.
Hassan S, Zhou XA. Drug-Induced Pigmentation. 2023 Jul 10. In: StatPearls(Internet). Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31194410.
Post inflammatory hyperpigmentation-Lawrence E, Al Aboud KM. Postinflammatory Hyperpigmentation. In: StatPearls(Internet). Treasure Island (FL): StatPearls Publishing; 2023 Jan.
Nautiyal A, Wairkar S. Management of hyperpigmentation: Current treatments and emerging therapies. Pigment cell & melanoma research. 2021 Nov;34(6):1000-14.
Kaur H, Aggarwal G, Nagpal M, Potential Benefits of Phytochemicals for Treatment of Hyperpigmentation, Journal of Drug Delivery and Therapeutics. 2019 Mar 15;9(2):420-7.
Syed Azhar SN, Ashari SE, Salim N. Development of a kojic monooleate-enriched oil-in-water nanoemulsion as a potential carrier for hyperpigmentation treatment. International journal of nanomedicine. 2018 Oct 15:6465-79.
Ghanbarzadeh S, Hariri R, Kouhsoltani M, Shokri J, Javadzadeh Y, Hamishehkar H. Enhanced stability and dermal delivery of hydroquinone using solid lipid nanoparticles. Colloids and surfaces B: biointerfaces. 2015 Dec 1;136:1004-10.
Sherpa, Lakpa Sangay, et al. "Liposomal drug delivery system: Method of preparations and applications." Journal of Pharmaceutical Sciences and Research 12.9 (2020): 1192-1197. Sherpa, Lakpa Sangay, et al. "Liposomal drug delivery system: Method of preparations and applications." Journal of Pharmaceutical Sciences and Research 12.9 (2020): 1192-1197.0
Kusumawardani A, Paramitasari AR, Dewi SR, Betaubun AI. The application of liposomal azelaic acid, 4-n butyl resorcinol and retinol serum enhanced by microneedling for treatment of malar pattern melasma: A case series. Dermatology Reports. 2019 Mar 29;11(s1).
Sobhi RM, Sobhi AM. A single‐blinded comparative study between the use of glycolic acid 70% peel and the use of topical nanosome vitamin C iontophoresis in the treatment of melasma. Journal of cosmetic dermatology. 2012 Mar;11(1):65-71.
Opatha, Shakthi Apsara Thejani, Varin Titapiwatanakun, and RomchatChutoprapat. "Transfersomes: A promising nanoencapsulation technique for transdermal drug delivery." Pharmaceutics 12.9 (2020): 855.
Nasir A, Harikumar SL, Amanpreet K. Niosomes: An excellent tool for drug delivery. international journal of research in pharmacy and chemistry. 2012;2(2):479-87.
Nainwal N, Jawla S, Singh R, Saharan VA. Transdermal applications of ethosomes–a detailed review. Journal of liposome research. 2019 Apr 3;29(2):103-13.
Mohammadi F, Giti R, Meibodi MN, Ranjbar AM, Bazooband AR, Ramezani V. Preparation and evaluation of kojic acid dipalmitate solid lipid nanoparticles. Journal of Drug Delivery Science and Technology. 2021 Feb 1;61:102183.
Zilles JC, Duarte LP, Ruaro TC, Zimmer AR, Kulkamp-Guerreiro IC, Contri RV. Nanoemulsion Containing Kojic Dipalmitate and Rosehip Oil: A Promising Formulation to Treat Melasma. Pharmaceutics. 2023 Jan 31;15(2):468.
Tanveer N, Khan HM, Akhtar N. Whitening effect of kojic acid dipalmitate loaded nanosized ethosomal gel for the treatment of hyperpigmentation: In vitro and in vivo characterization. Journal of Cosmetic Dermatology. 2022 Dec;21(12):6850-62.
Akib NI, Novianti C, Ritonga H, Adjeng AN. Optimization of method and proportion of phosphatidylcholine and ethanol for preparation of kojic acid ethosome. Research Journal of Pharmacy and Technology. 2020 Nov 1;13(11):5251-6.
Khan HM, Tanveer N, Arshad T, Rasool F, Uddin MN, Kazi M. Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: Invitro and invivo human studies. Heliyon. 2023 Sep 1;9(9).
Wen AH, Choi MK, Kim DD. Formulation of liposome for topical delivery of arbutin. Archives of pharmacal research. 2006 Dec;29:1187-92.
Radmard A, Saeedi M, Morteza-Semnani K, Hashemi SM, Nokhodchi A. An eco-friendly and green formulation in lipid nanotechnology for delivery of a hydrophilic agent to the skin in the treatment and management of hyperpigmentation complaints: Arbutin niosome (Arbusome). Colloids and Surfaces B: Biointerfaces. 2021 May 1;201:111616.
Talele P, Jadhav A, Tayade S, Sahu S, Sharma KK, Shimpi N. Hydroquinone loaded solid lipid nanoparticles comprised of stearic acid and ionic emulsifiers: Physicochemical characterization and in vitro release study. Journal of Molecular Liquids. 2022 Dec 15;368:120590
Taghavi F, Banihashemi M, Zabolinejad N, Salehi M, Jaafari MR, Marhamati H, Golnouri F, Dorri M. Comparison of therapeutic effects of conventional and liposomal form of 4% topical hydroquinone in patients with melasma. Journal of Cosmetic Dermatology. 2019 Jun;18(3):870-3.
Ammar AA, Salem HA, Eladawy SA, Elsamad Z, Kohaf NA. Development and clinical evaluation of topical hydroquinone niosomal gel formulation for the treatment of melasma. Int. J. App Pharm. 2020;12:228-36.
Jacobus Berlitz S, De Villa D, Maschmann Inacio LA, Davies S, Zatta KC, Guterres SS, Külkamp-Guerreiro IC. Azelaic acid-loaded nanoemulsion with hyaluronic acid–a new strategy to treat hyperpigmentary skin disorders. Drug development and industrial pharmacy. 2019 Apr 3;45(4):642-50.
Nautiyal A, Wairkar S. A reduced dose of Azelaic acid-loaded solid lipid nanoparticles for treatment of hyperpigmentation: In vitro characterization and cell line studies. Journal of Drug Delivery Science and Technology. 2023 Feb 1;80:104158.
Pasca PM, Antonescu A, Fritea L, Banica F, Vicas SI, Laslo V, Zaha DC, Cavalu S. Novel Liposomal Formulation with Azelaic Acid: Preparation, Characterization, and Evaluation of Biological Properties. Applied Sciences. 2022 Dec 19;12(24):13039.
Rahmi AD, Pangesti DM. Comparison of the characteristics of transfersomes and protransfersomes containing azelaic acid. Journal of Young Pharmacists. 2018;10(2s):S11.
Mistry A, Ravikumar P. Development and evaluation of azelaic acid based ethosomes for topical delivery for the treatment of acne. Indian J. Pharm. Educ. Res. 2016 Jul 1;50(3s):S232-43.
Zhang C, Lu Y, Ai Y, Xu X, Zhu S, Zhang B, Tang M, Zhang L, He T. Glabridin liposome ameliorating UVB-induced erythema and lethery skin by suppressing inflammatory cytokine production. Journal of Microbiology and Biotechnology. 2021 Apr 4;31(4):630.
Parvez S, Kang M, Chung HS, Cho C, Hong MC, Shin MK, Bae H. Survey and mechanism of skin depigmenting and lightening agents. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2006 Nov;20(11):921-34.
JJ N. The safety of hydroquinone. J EurAcad Dermatol Venereol. 2006;20:781-7.
Briganti S, Camera E, Picardo M. Chemical and instrumental approaches to treat hyperpigmentation. Pigment cell research. 2003 Apr;16(2):101-10.
Hemesath TJ, Price ER, Takemoto C, Badalian T, Fisher DE. MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature. 1998 Jan 15;391(6664):298-301.
Solano F, Briganti S, Picardo M, Ghanem G. Hypopigmenting agents: an updated review on biological, chemical and clinical aspects. Pigment cell research. 2006 Dec;19(6):550-71.
Draelos ZD. Skin lightening preparations and the hydroquinone controversy. Dermatologic therapy. 2007 Sep;20(5):308-13.
Badreshia-Bansal S, Draelos ZD. Insight into skin lightening cosmeceuticals for women of color. Journal of drugs in dermatology: JDD. 2007 Jan 1;6(1):32-9.
Picardo M, Carrera M. New and experimental treatments of cloasma and other hypermelanoses. Dermatologic clinics. 2007 Jul 1;25(3):353-62.
Petit L, Pierard GE. Skin‐lightening products revisited. International journal of cosmetic science. 2003 Aug;25(4):169-81.
Colby SI, Schwartzel EH, Huber FJ, Highton A, Altman DJ, Epinette WW, Lyon E. A promising new treatment for solar lentigines. Journal of Drugs in Dermatology: JDD. 2003 Apr 1;2(2):147-52.
Keeling J, Cardona L, Benitez A, Epstein R, Rendon M. Mequinol 2%/tretinoin 0.01% topical solution for the treatment of melasma in men: a case series and review of the literature. Cutis. 2008 Feb 1;81(2):179-83.
Couteau C, Coiffard L. Overview of skin whitening agents: Drugs and cosmetic products. Cosmetics. 2016 Jul 25;3(3):27.
Bashir F, Sultana K, Khalid M, Rabia H. Kojic acid: a comprehensive review. Asian Journal of Allied Health Sciences (AJAHS). 2021 Mar 19.
Khezri K, Saeedi M, Morteza-Semnani K, Akbari J, Hedayatizadeh-Omran A. A promising and effective platform for delivering hydrophilic depigmenting agents in the treatment of cutaneous hyperpigmentation: Kojic acid nanostructured lipid carrier. Artificial Cells, Nanomedicine, and Biotechnology. 2021 Jan 1;49(1):38-47.
Mohiuddin AK. Skin Lighteners & Hyperpigmentation Management. ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR). 2019;5(1):01-42.
Kim YJ, Uyama H. Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future. Cellular and molecular life sciences CMLS. 2005 Aug;62:1707-23.
Parvez S, Kang M, Chung HS, Bae H. Naturally occurring tyrosinase inhibitors: mechanism and applications in skin health, cosmetics and agriculture industries. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2007 Sep;21(9):805-16.
Ma NS, Abraham M, Choi MJ, Kim JS. Skin permeation and comparative evaluation of gentisic acid ester derivatives as skin-lightening agents. Journal of Drug Delivery Science and Technology. 2014 Jan 1;24(2):212-7.
Zhang J, Wu X, Zhong B, Liao Q, Wang X, Xie Y, He X. Review on the diverse biological effects of glabridin. Drug Design, Development and Therapy. 2023 Dec 31:15-37.
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