A Novel Approch for Nasal Drug Delivery System

Authors

  • Avinash Jadhav Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.
  • Prof.Vishweshwar Dharashive Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.
  • Dr.Sameer Shafi Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.
  • Saiprasad Chavan Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.
  • Madhav Honrao Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.
  • Rahul Inje Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.
  • Akshay Biradar Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

DOI:

https://doi.org/10.22270/ajprd.v12i2.1383

Abstract

The oral route is the most favored technique for administering the drug orally in the body. As a result of certain limitations such as drug absorption, poor bioavailability, first-pass hepatic metabolism and medicine target to particular organs, may cause problems for administration via oral route. Therefore parenteral route, transmucosal route and transdermal route are preferred over oral route. Intranasal route is deemed to be a desirable route because of the time profile of concentration a drug is close to that of the intravenous route. The nasal route has also been successfully used for bypassing the blood-brain barrier and afterword delivering drug molecules to the central nervous system .The in-situ gelling system is a process in which   is in a solution form before the administration in the body but it converts in to a gel form after administration . The formation of gel depends on factors like temperature modulation, pH change, presence of ions from which drug get released in sustained and controlled manner. Therefore this review focuses on nasal drug delivery, a variety of aspects of nasal anatomy and physiology, nasal absorption mechanism, and In-Situ gels evaluations.

 

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Author Biographies

Avinash Jadhav, Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

Prof.Vishweshwar Dharashive, Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

Dr.Sameer Shafi, Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

Saiprasad Chavan, Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

Madhav Honrao, Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

Rahul Inje , Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

Akshay Biradar , Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

Shivlingeshwar College of Pharmacy, Almala Tq. Ausa Dist. Latur – 413520, Maharashtra [MH], India.

References

Kaur P, Garg T, Rath G, Goyal AK. In situ nasal gel drug delivery: A novel approach for brain targeting through the mucosal membrane. Artificial cells, nanomedicine, and biotechnology. 2016 May 18;44(4):1167-76.

Sabale AS, Kulkarni AD, Sabale AS. Nasal in situ gel: novel approach for nasal drug delivery. Journal of Drug Delivery and Therapeutics. 2020 Apr 15;10(2-s):183-97.

Chand P, Gnanarajan G, Kothiyal P. In situ gel: A Review. Indian Journal of Pharmaceutical and Biological Research. 2016 Apr 1;4(2):11.

Nimi TN, Manohar DR. An overview on in-situ nasal gel for drug delivery. Journal of Pharmaceutical Sciences and Research. 2019 Jul 1;11(7):2585-9.

Salunke SR, Patil SB. Ion activated in situ gel of gellan gum containing salbutamol sulphate for nasal administration. International journal of biological macromolecules. 2016 Jun 1;87:41-7.

Ban MM, Chakote VR, Dhembre GN, Rajguru JR, Joshi DA. in-Situ Gel for Nasal Drug Delivery Original Research Article in-Situ Gel for Nasal Drug Delivery. 2018; (March).

Vibha B. In-situ gel nasal drug delivery system-a review. International Journal of Pharma Sciences. 2014;4(3):577-80.

Aderibigbe BA. In situ-based gels for nose to brain delivery for the treatment of neurological diseases. Pharmaceutics. 2018 Mar 30;10(2):40.

Patel Chirag, Dhruv Mangukia, Sojtra Ishita, Umesh Kumar. A Recent Review on Alternative system of parentral delivery: Nasal Drug Delivery System. Journal of Drug Descovery and Therapeutics, 2013; 1(1): 12-18.

Sarfraz Khan. Review: In-Situ gelling system. Journal of innovations in Pharmaceuticals and biological sciences (JIPBS), 2014; 1(2): 88-91.

More PK, Saudagar RB, Gondkar SB. Nasal In-Situ Gel: A Novel Approach for Nasal Drug Delivery System. World Journal of Pharmaceutical Research. 2014 Nov 21;4(2):686-708.

Panchal DR, Patel UL, Bhimani BV, Daslaniya DJ, Patel GV. Nasal in-situ gel: a novel drug delivery system. International Journal for Pharmaceutical Research Scholars. 2012;1(2):457-73.

Durgapal S, Rana M, Mukhopadhyay S, Rana AJ, Goswami L, Joshi S. Formulation and evaluation of in-situ nasal gel of montelukast sodium for the effective treatment of asthma. International Journal of Pharmaceutical Sciences and Research. 2018 Jul 1;9(7):2792-9.

Khandagale PM, Rokade MM, Phadtare DG. Formulation Development and Evaluation of Nasal In-Situ Gel of Hydrocortisone. Asian Journal of Pharmacy and Technology. 2018; 8(2):92-102.

Shah V, Sharma M, Pandya R, Parikh RK, Bharatiya B, Shukla A, Tsai HC. Quality by Design approach for an in situ gelling microemulsion of Lorazepam via intranasal route. Materials Science and Engineering: C. 2017 Jun 1; 75:1231-41.

Pathan IB, Mene H, Bairagi S. Quality by design (QbD) approach to formulate in situ gelling system for nose to brain delivery of Fluoxetine hydrochloride: Ex-vivo and In-vivo study. Ars Pharm. 2017; 58(3):107–14.

Abouhussein DM, Khattab A, Bayoumi NA, Mahmoud AF, Sakr TM. Brain targeted rivastigmine mucoadhesive thermosensitive In situ gel: Optimization, in vitro evaluation, radiolabeling, in vivo pharmacokinetics and biodistribution. Journal of Drug Delivery Science and Technology. 2018 Feb 1; 43:129-40.

Fatouh AM, Elshafeey AH, Abdelbary A. Agomelatine-based in situ gels for brain targeting via the nasal route: Statistical optimization, in vitro, and in vivo evaluation. Drug Delivery. 2017 Jan 1; 24(1):1077-85.

Pathan IB, More B. Formulation and characterization of intra nasal delivery of nortriptyline hydrochloride thermoreversible gelling system in treatment of depression. ACTA Pharmaceutica Sciencia. 2017;55(2).

Sherje AP, Londhe V. Development and evaluation of pH-responsive cyclodextrin-based in situ gel of paliperidone for intranasal delivery. AAPS PharmSciTech. 2018 Jan;19:384-94.

Durgapal S, Rana M, Mukhopadhyay S, Rana AJ, Goswami L, Joshi S. Formulation and evaluation of in-situ nasal gel of montelukast sodium for the effective treatment of asthma. International Journal of Pharmaceutical Sciences and Research. 2018 Jul 1;9(7):2792-9.

Patil RP, Pawara DD, Gudewar CS, Tekade AR. Nanostructured cubosomes in an in situ nasal gel system: an alternative approach for the controlled delivery of donepezil HCl to brain. Journal of liposome research. 2019 Jul 3;29(3):264-73.

Sri Chaya MV, Kumar A, Manjunath K, Kulkarni SV. Development characterization and evaluation of nasal in situ gel containing anti-asthmatic drug. Int J Pharma Res Health Sci. 2019;7(3):3001-6.

Karpagavalli L, Gopalasrsatheeskumar K, Narayanan N, Maheswaran A, Raj AI, Priya JH. Formulation and evaluation of zolpidem nasal in situ gel. World J Pharm Res. 2017;6(2).

Rajput AP, Butani SB. Resveratrol anchored nanostructured lipid carrier loaded in situ gel via nasal route: Formulation, optimization and in vivo characterization. Journal of drug delivery science and technology. 2019 Jun 1; 51:214-23.

Shinde JV, Mali KK, Dias RJ, Havaldar VD, Mahajan NS. In situ mucoadhesive nasal gels of metoclopramide hydrochloride: preformulation and formulation studies. J Pharm Res. 2008 Jul;1(1):88-96.

Mahajan HS, Gattani S. In situ gels of metoclopramide hydrochloride for intranasal delivery: in vitro evaluation and in vivo pharmacokinetic study in rabbits. Drug delivery. 2010 Jan 1; 17(1):19-27.

Khan S, Patil K, Bobade N, Yeole P, Gaikwad R. Formulation of intranasal mucoadhesive temperature-mediated in situ gel containing ropinirole and evaluation of brain targeting efficiency in rats. Journal of drug targeting. 2010 Apr 1; 18(3):223-34.

Sharma S, Lohan S, Murthy RS. Formulation and characterization of intranasal mucoadhesive nanoparticulates and thermo-reversible gel of levodopa for brain delivery. Drug development and industrial pharmacy. 2014 Jul 1; 40(7):869-78.

Kaur P, Garg T, Vaidya B, Prakash A, Rath G, Goyal AK. Brain delivery of intranasal in situ gel of nanoparticulated polymeric carriers containing antidepressant drug: behavioral and biochemical assessment. Journal of drug targeting. 2015 Mar 16;23(3):275-86.

Naik A, Nair H. Formulation and evaluation of thermosensitive biogels for nose to brain delivery of doxepin. BioMed research international. 2014 Oct;2014.

Verma P, Prashar N, Kumar V, Chaudhary H. Nasal (In-situ) gel (Phenylepherine HCl) for allergic rhinitis congestion treatment: development and characterization. Am. J. PharmTech Res. 2016; 6:1-7.

Jagdale S, Shewale N, Kuchekar BS. Optimization of thermoreversible in situ nasal gel of timolol maleate. Scientifica. 2016 Jan 1; 2016.

Rao M, Agrawal DK, Shirsath C. Thermoreversible mucoadhesive in situ nasal gel for treatment of Parkinson’s disease. Drug development and industrial pharmacy. 2017 Jan 2; 43(1):142-50..

Lungare S, Bowen J, Badhan R. Development and evaluation of a novel intranasal spray for the delivery of amantadine. Journal of Pharmaceutical Sciences. 2016 Mar 1; 105(3):1209-20.

Published

2024-04-15

How to Cite

Jadhav, A., Dharashive, P., Shafi, D., Chavan, S., Honrao, M., Inje , R., & Biradar , A. (2024). A Novel Approch for Nasal Drug Delivery System. Asian Journal of Pharmaceutical Research and Development, 12(2), 96–106. https://doi.org/10.22270/ajprd.v12i2.1383

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