Formulation and Evaluation of Olanzapine Liquisolid Tablets for Improving Dissolution
DOI:
https://doi.org/10.22270/ajprd.v13i4.1615Abstract
The oral route remains the most preferred method for drug administration due to its ease, cost-effectiveness, and patient compliance. However, drugs with poor aqueous solubility have challenges to oral bioavailability and therapeutic efficacy. Bioavailability is mostly affected by drug dissolution and its release from the dosage form, and it mainly depends on solubility of drug. For the development of new pharmaceutical products, the major issue any pharmaceutical industry faces are solubility, which ultimately results in low bioavailability. There are various methods to enhanced solubility such as micronization, nanonization, self-emulsification, solid dispersion, co-solvency, solid lipid nanoparticles, co-precipitation technique, particle size reduction and complexation all have been used in recent research to increase the solubility of the drug, but the liquisolid compact has demonstrated superior results for enhancing dissolution. Liquisolid technology is a novel and promising approach used to treat low dose with poorly soluble drugs. OLZ is a BCS Class-II drug prescribed for Schizophrenia, depression, and bipolar disorder. The present study aims to enhance the solubility and dissolution rate of Olanzapine using the Liquisolid Compact Technique. Four formulation batches of OLZ liquisolid tablets were prepared using Tween 80 as non-volatile solvent, Fujicalin as carrier material and Aerosil 200 as coating material and evaluated for general appearance, thickness, hardness, friability, Average weight, disintegration, content uniformity, in-vitro drug release. A drug having a low dose can be formulated by this method.
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References
Katzung BG, Masters SB, Trevor AJ. Basic and Clinical Pharmacology. 12th ed. New York: McGraw-Hill Education; 2012.
Allen LV, Popovich NG, Ansel HC. Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. 10th ed. Philadelphia: Lippincott Williams & Wilkins; 2013.
Brahmankar HA, Jaiswal SB. Biopharmaceutics and Pharmacokinetics: A Treatise. 2nd ed. New Delhi: Vallabh Prakashan; 2009.
Dressman JB, Lennernäs H. Oral Drug Absorption: Prediction and Assessment. 2nd ed. London: Informa Healthcare; 2009.
Patil JS, Kadam DV, Marapur SC, Kamalapur MV. Recent advances in drug delivery systems: a review. Int J Pharm Pharm Sci. 2010;2(4):30-5.
Pouton CW. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur J Pharm Sci. 2006;29(3-4):278-87.
Zhang X, Xing H, Zhao Y, Ma Z. Pharmaceutical dispersion techniques for dissolution and bioavailability enhancement of poorly water-soluble drugs. Pharmaceutics. 2018;10(3):74.
Patel CJ, Asija R, Asija S. Different methods of enhancement of solubilization and bioavailability of poorly soluble drugs: a recent review. Pharmatutor. 2012; 1424.
Jouyban A. Solubility of drugs in water–cosolvent mixtures. Expert Opin Drug Metab Toxicol. 2008;4(3):297-305.
Allen LV, Popovich NG, Ansel HC. Ansel’s Pharmaceutical Dosage Forms and Drug Delivery Systems. 9th ed. Philadelphia: Lippincott Williams & Wilkins; 2011.
Spireas S. Liquisolid systems and methods of preparing same. U.S. Patent No. 6,423,339; 2002.
Javadzadeh Y, Siahi MR, Asnaashari S, Nokhodchi A. An investigation of physicochemical properties of piroxicam liquisolid compacts. Pharmacol Res. 2007;56(5):493–8.
Vijaykumar N, Ramarao T, Jayaveera KN. Liquisolid compacts: a novel approach to enhance bioavailability of poorly soluble drugs. Int J Pharm Biol Sci. 2011; 1:89–102.
Nokhodchi A, Hentzschel CM, Leopold CS. Drug release from liquisolid systems: speed it up, slow it down. Expert Opin Drug Deliv. 2011;8(2):191–205.
Nagamani HB, Ganesh NS, Chandy V. Liquisolid technique: A novel approach to enhance solubility. World J Pharm Res. 2019;8(13):1–11.
Kasturi M. Development of liquisolid compacts: an approach for dissolution enhancement of poorly aqueous soluble drugs. In: Intech Open; 2022. p.1–23.
Rashad A, Louis D. An overview on liquisolid technique: its development and applications. Ther Deliv. 2023.
Pingtian D, Dongkai W, Mei L, Haonan X, Jingzheng J, Xiao C, et al.; Liquisolid technique and its applications in pharmaceutics.; Asian J Pharm Sci 2016; 9:1-9.
Sharma S. Tablets. In: Industrial Pharmacy-I. Nagpur: PV Publication; 2019. p.41–8.
Sheikh AA, Usman RM, Biyani KR. Practical Book of Industrial Pharmacy - I. Nagpur: Pee Vee Publication; p.1–8.
Deppeler HP. Hydrochlorothiazide. In: Analytical Profile of Drug Substances; p.405–41.
Khan A, Iqbal Z, Ullah A, Khadra I, Sherazi M, Zeb N. Discriminatory dissolution testing for liquisolid compacts containing a poorly water-soluble drug (hydrochlorothiazide). Dissolut Technol. 2019;26(1):46–54.
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