Nutraceuticals: -In Skin Care and Formulations A Review
DOI:
https://doi.org/10.22270/ajprd.v13i5.1645Abstract
The physiologically active ingredients that sustain health advantages are known as nutraceutical. Due to their therapeutic benefits, these products are crucial to human health care. The nutritional advantages, medicinal effects, and safety profile of nutraceuticals have earned them prominence. Nutraceuticals are well known throughout the world and are expanding in the sphere of services like illness prevention and health care promotion. For a better knowledge of nutraceuticals, this review has also provided instances and explanations of numerous drug nutraceutical interactions. Numerous nutraceutical patents have been filed in a variety of agricultural and medical fields. In addition to being used for nutrition, nutraceuticals have been used as a support therapy for the prevention and treatment of a number of illnesses, including to lessen the negative effects of chemotherapy for cancer. Micronized food items and other nutraceutical supplements with enhanced health advantages are also produced thanks to nanotechnology.
There has also been discussion of the most recent important discoveries (clinical research) on nutraceuticals that demonstrate the therapeutic effect of the bioactive compounds in these products on a range of illnesses.
Numerous internal and environmental factors, including hormone imbalances, UV radiation, and the biological evolution of cells, all contribute to the ongoing aging of the skin. These internal and external factors increase the appearance of aging skin, which is characterized by telangiectasias, wrinkles, roughness, loss of elasticity, and diminished firmness. Nutraceuticals have been researched all year long to combat and postpone a number of food-related issues.
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Goldie K, Kerscher M, Fabi SG, Hirano C, Landau M, Lim TS, et al. Skin quality—A holistic 360° view: Consensus results. Clin CosmetInvestig Dermatol. 2021;14:643–654.
Makrantonaki E, Vogel M, Scharffetter-Kochanek K, Zouboulis CC. Skin aging: Molecular understanding of extrinsic and intrinsic processes. Hautarzt. 2015;66:730–737.
Cao C, Xiao Z, Wu Y, Ge C. Diet and skin aging—From the perspective of food nutrition. Nutrients. 2020;12:870.
Petruk G, Del Giudice R, Rigano MM, Monti DM. Antioxidants from plants protect against skin photoaging. Oxid Med Cell Longev. 2018;2018:1454936.
Kalra EK. Nutraceutical—Definition and introduction. AAPS PharmSci. 2003;5:E25.
Clair JS. A new model of tracheostomy care: Closing the research–practice gap. In: Henriksen K, Battles JB, Marks ES, Lewin DI, editors. Advances in patient safety: From research to implementation. Vol. 3. Rockville (MD): Agency for Healthcare Research and Quality (US); 2005. Available from: https://www.ncbi.nlm.nih.gov/books/NBK20542/
Schölmerich J. MedizinischeTherapie, Sektion I Prinzipien der Therapie, EvidenzbasierteMedizin. In: Schölmerich J, editor. MedizinischeTherapie. Berlin/Heidelberg: Springer; 2007. p. 1–19.
Oxford Centre for Evidence-Based Medicine. Levels of Evidence. Oxford (UK): Centre for Evidence-Based Medicine; 2009.
GD Society for Dermopharmacy. Dermocosmetics Against Skin Aging: Guideline. 2017. Available from: https://www.gd-online.de/german/veranstalt/images2017/GD_LL_Dermokosmetika_gegen_Hautalterung_13.03.2017.pdf
Deutsche Gesellschaft für Ernährunge.V. (DGE). Referenzwerte für die Nährstoffzufuhr. 2019. Available from: http://www.dge.de/wissenschaft/referenzwerte/
Genovese L, Sibilla S. Innovative nutraceutical approaches to counteract the signs of aging. In: Farage M, Miller K, Maibach H, editors. Textbook of Aging Skin. Berlin/Heidelberg: Springer; 2016. p. 1–25.
Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, Zinc. Washington (DC): National Academy Press; 2001.
Chauhan B, Kumar G, Kalam N, Ansari SH. Current concepts and prospects of herbal nutraceutical: A review. J Adv Pharm Technol Res. 2013;4:4–8.
NIH Office of Dietary Supplements. Vitamin C Fact Sheet for Health Professionals. Updated 26 March 2021. Available from: https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/
Wang K, Jiang H, Li W, Qiang M, Dong T, Li H. Role of vitamin C in skin diseases. Front Physiol. 2018;9:819.
Tebbe B, Wu S, Geilen CC, Eberle J, Kodelja V, Orfanos CE. L-ascorbic acid inhibits UVA-induced lipid peroxidation and secretion of IL-1α and IL-6 in cultured human keratinocytes. J Invest Dermatol. 1997;108:302–306.
Mireles-Rocha H, Galindo I, Huerta M, Trujillo-Hernández B, Elizalde A, Cortés-Franco R. UVB photoprotection with antioxidants: Effects of oral therapy with d-α-tocopherol and ascorbic acid on the minimal erythema dose. Acta Derm Venereol. 2002;82:21–24.
Bertuccelli G, Zerbinati N, Marcellino M, Nanda Kumar NS, He F, Tsepakolenko V, et al. Effect of a quality-controlled fermented nutraceutical on skin aging markers: An antioxidant-control, double-blind study. Exp Ther Med. 2016;11:909–916.
Lauer AC, Groth N, Haag SF, Darvin ME, Lademann J, Meinke MC. Dose-dependent vitamin C uptake and radical scavenging activity in human skin measured with in vivo electron paramagnetic resonance spectroscopy. Skin Pharmacol Physiol. 2013;26:147–154.
Natarajan VT, Ganju P, Ramkumar A, Grover R, Gokhale RS. Multifaceted pathways protect human skin from UV radiation. Nat Chem Biol. 2014;10:542–551.
Cichorek M, Wachulska M, Stasiewicz A, Tyminska A. Skin melanocytes: Biology and development. Postepy Dermatol Alergol. 2013;30:30–41.
Singh TP, Zhang HH, Borek I, Wolf P, Hedrick MN, Singh SP, et al. Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation. Nat Commun. 2016;7:13581.
Labat-Robert J. Information exchanges between cells and extracellular matrix. Influence of ageing. Biol Aujourdhui. 2012;206:103–109.
Kim SH, Turnbull J, Guimond S. Extracellular matrix and cell signalling: The dynamic cooperation of integrin, proteoglycan and growth factor receptor. J Endocrinol. 2011;209:139–151.
Quan T, Fisher GJ. Role of age-associated alterations of the dermal extracellular matrix microenvironment in human skin ageing: A mini-review. Gerontology. 2015;61:427–434.
Smart Servier Medical Art. Available from: https://smart.servier.com/
D’Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation and the skin. Int J Mol Sci. 2013;14:12222–12248.
Holick MF. Sunlight, UV-radiation, vitamin D and skin cancer: How much sunlight do we need? Adv Exp Med Biol. 2008;624:1–15.
Juzeniene A, Moan J. Beneficial effects of UV radiation other than via vitamin D production. Dermatoendocrinol. 2012;4:109–117.
Gupta A, Avci P, Dai T, Huang YY, Hamblin MR. Ultraviolet radiation in wound care: Sterilization and stimulation. Adv Wound Care (New Rochelle). 2013;2:422–437.
Diffey BL. Solar ultraviolet radiation effects on biological systems. Phys Med Biol. 1991;36:299–328.
Slominski A, Wortsman J. Neuroendocrinology of the skin. Endocr Rev. 2000;21:457–487.
Slominski A, Wortsman J, Luger T, Paus R, Solomon S. Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev. 2000;80:979–1020.
Slominski AT, Zmijewski MA, Skobowiat C, Zbytek B, Slominski RM, Steketee JD. Sensing the environment: Regulation of local and global homeostasis by the skin’s neuroendocrine system. Adv Anat Embryol Cell Biol. 2012;212:1–115.
Clydesdale GJ, Dandie GW, Muller HK. Ultraviolet light-induced injury: Immunological and inflammatory effects. Immunol Cell Biol. 2001;79:547–568.
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