Preparation and Characterization of Spherical Crystals of Simvastatin To Enhance The Solubility and Micrometric Properties

Authors

  • Kunal K. Janrao Department of Quality Assurance VJSM’s, Vishal Institute of Pharmaceutical Education and Research, Ale, Pune
  • M V Gadhave Department of Quality Assurance VJSM’s, Vishal Institute of Pharmaceutical Education and Research, Ale, Pune
  • S K Banerjee Department of Quality Assurance VJSM’s, Vishal Institute of Pharmaceutical Education and Research, Ale, Pune
  • D D Gaikwad Department of Quality Assurance VJSM’s, Vishal Institute of Pharmaceutical Education and Research, Ale, Pune

Keywords:

Simvastatin, spherical agglomeration technique, solubility, dissolution, micromeritic properties

Abstract

Simvastatin is an Antihyperlipidemic commonly used in the treatment of hypercholesterolemia and dyslipidemia. Due to low solubility in water and poor micrometric properties of Simvastatin leads to low dissolution rate. The aim of present investigation was to improve solubility, dissolution rate and enhancement of micromeritic properties of the poorly solvable drug. The parameters optimized were type, extent, and method of addition of bridging agent. The spherical agglomerate/crystals of Simvastatin were prepared by solvent change method in the presence of hydrophilic polymer in different concentration. The solvent system used was Ethanol, water and chloroform as good solvent, antisolvent and bridging liquid respectively. Spherical agglomerates were subjected for determination of percent drug content and particle size analysis. The agglomerates were also characterized by Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), X-ray Powder Diffraction (XRD) and Scanning Electron Microscopy (SEM) analysis. The FTIR and DSC study showed no interaction between drug and polymer. XRD studies showed a slight decrease in crystallinity in agglomerates. Spherical agglomerates showed improvement in solubility, dissolution rate and micromeritic properties in comparison to that of the pure drug. The SEM also showed that the agglomerate possess a good spherical shape.

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Published

2014-03-01

How to Cite

Janrao, K. K., Gadhave, M. V., Banerjee, S. K., & Gaikwad, D. D. (2014). Preparation and Characterization of Spherical Crystals of Simvastatin To Enhance The Solubility and Micrometric Properties. Asian Journal of Pharmaceutical Research and Development, 2(2), 96–104. Retrieved from https://www.ajprd.com/index.php/journal/article/view/174

Issue

Volume 2nd Issue 2nd March-April 2014

Section

Research Articles

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