Synthesis and Biological Evaluation of Novel Indole Derivatives for Anticancer and Antitubercular Activty

Authors

  • Aditya Dixit Department of Pharmaceutical chemistry, B. S. Anangpuria Institute of Pharmacy, Faridabad
  • D Pathak Department of Pharmaceutical chemistry, Rajiv Academy for Pharmacy, Mathura
  • G. K Sharma Department of Pharmaceutical chemistry, Rajiv Academy for Pharmacy, Mathura

Keywords:

Indole, Antitubercular activity, Anticancer activity

Abstract

A series of substituted indole derivatives were synthesized by condensation of 2-(o-Aminophenyl)indole with various benzaldehydes to form N-(Arylidine)-2-(1H indol-2-yl)-benzenamines (2a-2l) which further react with isatin and ammonium acetate to give 3-[2-(1H-Indol-2-yl)phenyl]-2aryl-imidazo[4,5-b]indoles (3a-3l). The synthesized compounds were characterized by FTIR, 1HNMR, mass spectra and elemental analysis. At last, all end products were evaluated for the antitubercular and anticancer activities

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Published

2014-03-01

How to Cite

Dixit, A., Pathak, D., & Sharma, G. K. (2014). Synthesis and Biological Evaluation of Novel Indole Derivatives for Anticancer and Antitubercular Activty. Asian Journal of Pharmaceutical Research and Development, 2(2), 141–145. Retrieved from https://www.ajprd.com/index.php/journal/article/view/177

Issue

Volume 2nd Issue 2nd March-April 2014

Section

Research Articles

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