Sorption Promoters: A Novel Enhancer Approach for Topical Drug Delivery System
Keywords:
Topical Drug Delivery, Skin, Stratum Corneum Modification, Penetration Enhancers, BioavailabilityAbstract
Topical drug delivery system can be defined as direct effects of formulation or drug containing medication to the skin to get localizing effect of drug or directly cure cutaneous disorders. The skin has evolved to prevent excessive water loss from the internal organs and to limit the ability of xenobiotics and hazardous substances to enter the body. Notwithstanding this barrier function, a number of strategies have been developed by scientists to deliver drugs to and through the skin. Skin as an important site for topical effects so there is considerable interest in the skin for local and systemic effect of drug application. However, in the skin, the stratum corneum is the main barrier for drug penetration there by limiting topical and transdermal bioavailability. Skin penetration enhancement techniques have been developed to improve bioavailability and increase the range and number of drugs available for both topical and transdermal delivery. In this review, we have discussed about the various penetration enhancers, their mechanism of action and their potential for clinical application.
Downloads
Published
How to Cite
Issue
Section
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).