Formulation of Gastro Retentive Floating Microballoons of Ciprofloxacin Hydrochloride

Authors

  • Anand Pradeep Department of Pharmaceutics, University College of Pharmacy, RIMSR, Puthupally, Kottayam, Kerala, India.
  • Sreeganesan . Department of Pharmaceutics, University College of Pharmacy, RIMSR, Puthupally, Kottayam, Kerala, India.

Keywords:

Ciprofloxacin HCL, Fluroquinolone, microballoons

Abstract

The present study involves formulation of microbaloons of Ciprofloxacin HCL as a model drug for prolongation of Gastric resident time. Ciprofloxacin is a second generation Fluroquinolone having bactericidal activity and is used in the treatment of respiratory, urinary tract, gastrointestinal and abdominal infections including Gram-negative (Escherichia coli) and Gram-positive (Streptococcus pneumonia, Streptococcus pyogenes) bacterial pathogens. Ciprofloxacin HCl with pKa value of 4.9 is a weak acid which will remain unionized at acidic pH thus increases absorption in the stomach region. It is primarily absorbed from the stomach and upper part of intestine. The objective of the study was to formulate the microbaloons which are capable of floating on the gastric fluid and release the drug over a period of 24 hours thus increasing bioavailability and decreasing the frequency of dosage. The compatability of Ciproflocxacin HCl and polymers is studied by IR spectroscopy and DSC methods. Microbaloons were formulated by Emulsion solvent diffusion methods using polymers like Eudragit RS100 and Eudragit RL100 in various ratios.

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Published

2015-03-01

How to Cite

Pradeep, A., & ., S. (2015). Formulation of Gastro Retentive Floating Microballoons of Ciprofloxacin Hydrochloride. Asian Journal of Pharmaceutical Research and Development, 3(2), 1–12. Retrieved from https://www.ajprd.com/index.php/journal/article/view/236

Issue

Volume 3rd Issue 2nd Mar-Apr 2015

Section

Research Articles

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