Review: Non-Invasive Therapy for Diabetes Mellitus Using Solid Lipid Nanoparticle

Authors

  • S. S. KAMBLE Department of Pharmaceutics, Sinhgad College of Pharmacy, Pune-41.
  • M. S. GAMBHIRE Department of Pharmaceutics, Sinhgad College of Pharmacy, Pune-41
  • K. N. GUJAR Department of Pharmaceutics, Sinhgad College of Pharmacy, Pune-41
  • M. H. AFSHINFAR Department of Pharmaceutics, Sinhgad College of Pharmacy, Pune-41

Keywords:

Diabetes, GI tract, Insulin, Nanoparticle, Oral delivery

Abstract

Oral delivery of Insulin as a non-invasive therapy for Diabetes Mellitus is still a challenge for the drug delivery technology, as it is degraded due to the presence of enzymes in the acidic environment of stomach and also its absorption through the gastrointestinal mucosa is doubtful.Advancements in nanotechnology have brought the scientist ever closer to this goal.The current review focuses on the various barriers existing in the route of oral insulin delivery and the strategies undertaken so far to overcome those by nanoparticle as potential vehicles of insulin. The oncoming years shall be interesting in the form of more oral insulin preparations actually becoming available and affordable to those thousands who are awaiting a relief from the stress and distress of daily insulin injections.

Downloads

Download data is not yet available.

Published

2015-03-01

How to Cite

KAMBLE, S. S., GAMBHIRE, M. S., GUJAR, K. N., & AFSHINFAR, M. H. (2015). Review: Non-Invasive Therapy for Diabetes Mellitus Using Solid Lipid Nanoparticle. Asian Journal of Pharmaceutical Research and Development, 3(2), 38–48. Retrieved from https://www.ajprd.com/index.php/journal/article/view/239

Issue

Volume 3rd Issue 2nd Mar-Apr 2015

Section

Research Articles

AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

Most read articles by the same author(s)