MAGNETIC AND pH SENSITIVE NANOPARTICLES FOR CANCER DRUG DELIVERY
DOI:
https://doi.org/10.22270/ajprd.v7i4.540Keywords:
pH responsive polymers; nanomedicine; Mesoporous nanoparticles, tumor imaging; drug deliveryAbstract
Cancer remains a leading cause of death worldwide with more than 10 million new cases every year. Tumor-targeted nanomedicines have shown substantial improvements of the therapeutic index of anticancer agents, addressing the deficiencies of conventional chemotherapy, and have had a tremendous growth over past several decades. Due to the pathophysiological characteristics that almost all tumor tissues have lower pH in comparison to normal healthy tissues, among various tumor-targeted nanomaterials, pH-responsive polymeric materials have been one of the most prevalent approaches for cancer diagnosis and treatment. In this review, we summarized the types of pH-responsive polymers, describing their chemical structures and pH-response mechanisms; we illustrated the structure-property relationships of pH-responsive polymers and introduced the approaches to regulating their pH-responsive behaviors; we also highlighted the most representative applications of pH-responsive polymers in cancer imaging and therapy. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release and avoid premature release. Here, we focus on the use of the subtle changes of pH between healthy and diseased areas along the body to trigger the release of the cargo. The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment.
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13. Chen Y, Shi J. Mesoporous carbon biomaterials. Sci. China Mater. 2015; (58):241–257.
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19. He D He X Wang K, Cao J, Zhao Y. A light-responsive reversible molecule-gated system using thymine-modified mesoporous silica nanoparticles. Langmuir 2012; (28):4003–4008.
20. Martínez-Carmona, M, Baeza A, Rodriguez-Milla MA, García-Castro J, Vallet-Regí M. Mesoporous silica nanoparticles grafted with a light-responsive protein shell for highly cytotoxic antitumoral therapy. J. Mater. Chem. B 2015; (3):5746–5752.
21. Paris JL, Cabañas MV, Manzano M, Vallet-Regí M. Polymer-Grafted Mesoporous Silica Nanoparticles as Ultrasound-Responsive Drug Carriers. ACS Nano 2015; (9):11023–11033.
22. Guisasola E, Baeza A, Talelli M, Arcos D, Vallet-Regí M. Design of thermoresponsive polymeric gates with opposite controlled release behaviors. RSC Adv. 2016; 6:42510–42516.
23. Guisasola E, Baeza A, Talelli M, Arcos D, Moros M, De La Fuente JM, Vallet-Regí M. Magnetic-Responsive Release Controlled by Hot Spot Effect. Langmuir 2015; (31): 12777–12782.
24. Gondi CS, Rao, J.S. Cathepsin B as a cancer target. Expert Opin. Ther. Targets 2013; (17): 281–291.
25. Huo, M.; Yuan, J.; Tao, L.; Wei, Y. Redox-responsive polymers for drug delivery: From molecular design to applications. Polym. Chem. 2014; (5):1519.
26. Liu, J.; Zhang, B.; Luo, Z.; Ding, X.; Li, J.; Dai, L.; Zhou, J.; Zhao, X.; Ye, J.; Cai, K. Enzyme responsive mesoporous silica nanoparticles for targeted tumor therapy in vitroandin vivo. Nanoscale2015; (7):3614–3626.
27. Liu, Y.; Ding, X.; Li, J.; Luo, Z.; Hu, Y.; Liu, J.; Dai, L.; Zhou, J.; Hou, C.; Cai, K. Enzyme responsive drug delivery system based on mesoporous silica nanoparticles for tumor therapy in vivo. Nanotechnology 2015; (26):145102.
28. Li, Z.-Y.; Hu, J.-J.; Xu, Q.; Chen, S.; Jia, H.-Z.; Sun, Y.-X.; Zhuo, R.-X.; Zhang, X.-Z. A redox-responsive drug delivery system based on RGD containing peptide-capped mesoporous silica nanoparticles. J.Mater. Chem.B 2015; (3):39–44.
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Published
2019-08-15
How to Cite
Jadhao, A. G., Bhosale, A. G., Sitaphale, G. R., Rajguru, J. R., Sonali, S. A., & S. V. Deshmane, S. V. (2019). MAGNETIC AND pH SENSITIVE NANOPARTICLES FOR CANCER DRUG DELIVERY. Asian Journal of Pharmaceutical Research and Development, 7(4), 60–71. https://doi.org/10.22270/ajprd.v7i4.540
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Review Articles
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