Development, Characterization and Dissolution Study of Solid Dispersion of Diclofenac Sodium by Kneading Technique

Authors

  • Gajendra Singh Department of Pharmaceutics, Kota College of Pharmacy, Kota, Rajasthan, India
  • M.P. Khinchi Department of Pharmaceutics, Kota College of Pharmacy, Kota, Rajasthan, India
  • Dilip Agrawal Department of Pharmaceutics, Kota College of Pharmacy, Kota, Rajasthan, India
  • Natasha Sharma Department of Pharmaceutics, Kota College of Pharmacy, Kota, Rajasthan, India
  • Adil Hussain Department of Pharmaceutics, Kota College of Pharmacy, Kota, Rajasthan, India

Keywords:

Diclofenac sodium, Solid dispersion, Drug release study

Abstract

The present investigation was aimed to dissolution enhancement of diclofenac sodium by using Solid dispersion Technique using Mannitol, Sodium starch glycolate,Polymer.using in this technique. Solid dispersion are done by kneading method and solvent evaporation method..The solid dispersion characterized by particle size analysis,Drug content, in vitro and in vivo pharmacokinetic studies. .Highest dissolution is found in f 1 formulation in Phosphate buffer Ph 6.8 as compared to other formulation.

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Published

2013-03-01

How to Cite

Singh, G., Khinchi, M., Agrawal, D., Sharma, N., & Hussain, A. (2013). Development, Characterization and Dissolution Study of Solid Dispersion of Diclofenac Sodium by Kneading Technique. Asian Journal of Pharmaceutical Research and Development, 1(2), 97–102. Retrieved from https://www.ajprd.com/index.php/journal/article/view/57

Issue

Section

Research Articles

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