Comparative Cardiotonic Activity of Gymnema Sylvestre With Digoxin On Isolated Frog Heart

Authors

  • Shravan Kumar Dholi Department of Pharmacology, Vaageswari Institute of Pharmaceutical Sciences, Beside LMD Police Station, Ramakrishna Colony, Karimnagar, Andra Pradesh , India.
  • Prasanna laxmi. K Department of Pharmacology, Vaageswari Institute of Pharmaceutical Sciences, Beside LMD Police Station, Ramakrishna Colony, Karimnagar, Andra Pradesh , India.
  • Ashok. V Department of Pharmacology, Vaageswari Institute of Pharmaceutical Sciences, Beside LMD Police Station, Ramakrishna Colony, Karimnagar, Andra Pradesh , India.
  • Vidhyasree. B Department of Pharmacology, Vaageswari Institute of Pharmaceutical Sciences, Beside LMD Police Station, Ramakrishna Colony, Karimnagar, Andra Pradesh , India.
  • Naresh . Department of Pharmacology, Vaageswari Institute of Pharmaceutical Sciences, Beside LMD Police Station, Ramakrishna Colony, Karimnagar, Andra Pradesh , India.

Keywords:

Cardiotonic activity, Digoxin, Gymnema Sylvestre, Isolated frog heart

Abstract

Gymnema Sylvestre (GS) is commonly used herb in Ayurveda. Chewing the leaves actually deadens the sense of sweet tastes and also the bitterness of bitter substances .This property is believed to be due to a glycoside known as gymnemic acid. Gymnemic acid (a mixture of triterpene glucuronides, which was found in the leaves. Present study was carried out to determine the cardiotonic activity by using infusion of G.S with different dilutions & compared with cardiotonic activity of digoxin‐the life saving cardiotonic. The activity was tested by using iso lated frog heart assembly. The present preliminary studies confirm the better cardiotonic activity of Gymnema Sylvestre than digoxin. Further studies can confirm the reduced toxicity & this will be the advantage of G.S over digitalis. Thus, in future it will be interesting to isolate the active chemical constituents which are responsible for the cardiotonic activity.

Downloads

Download data is not yet available.

Published

2013-03-01

How to Cite

Dholi, S. K., K, P. laxmi., V, A., B, V., & ., N. (2013). Comparative Cardiotonic Activity of Gymnema Sylvestre With Digoxin On Isolated Frog Heart. Asian Journal of Pharmaceutical Research and Development, 1(2), 143–147. Retrieved from https://www.ajprd.com/index.php/journal/article/view/58

Issue

Volume 1st, Issue 2nd, Mar-Apr 2013

Section

Research Articles

AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).