EFFECT OF ZONISAMIDE ON CHRONIC CONSTRICTION INJURY INDUCED NEUROPATHIC PAIN IN MALE SD RATS

Authors

  • Sachin Goyal Pacific College of Pharmacy, Udaipur, Rajasthan, India
  • Gurudas Khilnani GMERS Medical College, Dharpur, Patan, Gujarat, India
  • Chain S Bais Faculty of Pharmaceutical Sciences, Jodhpur National University, Jodhpur, Rajasthan, India
  • Indrajeet Singhvi Pacific College of Pharmacy, Udaipur, Rajasthan, India
  • Shivali Singla SMS Medical College, Jaipur, Rajasthan, India
  • Hardik Patel Pacific College of Pharmacy, Udaipur, Rajasthan, India
  • Ajeet Kumar Khilnani GMERS Medical College, Dharpur, Patan, Gujarat, India

Keywords:

Neuropathic pain, Allodynia, Hyperalgesia, T-type Ca 2 channel, Zonisanmide, Pregabalin

Abstract

There is considerably research evidence supporting a palliative role for voltage-gated sodium and T-type calcium channels in neuropathic pain conditions. Hence, the present study was undertaken to assess the ability of zonisamide (a sodium and Ttype calcium channel blocker) to relieve various symptoms of neuropathic pain in the chronic constriction injury rat model of neuropathic pain. Zonisamide (80 & 50 mg/kg) or saline was administered in a blinded, randomized manner by intraperitoneal injection from postoperative day (POD) 7 to 13. Paw withdrawal duration (PWD) to spontaneous pain, chemical allodynia and mechanical hyperalgesia, and paw withdrawal latency (PWL) to mechanical allodynia and thermal hyperalgesia were tested before surgery, before and after zonisamide or saline administration (from POD7 to 13) and after the withdrawal of treatment (from POD14 to 36). Systemic zonisamide relived neuropathic pain symptoms in a dose dependent manner. All PWDs were significantly decreased and PWLs were significantly increased after zonisamide administration compared with saline control measurements. However, zonisamide had non-uniform effect on chemical allodynia. Results of zonisamide were also compared with standard drug pregabalin (50 & 30 mg/kg) and found that zonisamide should be considered as an ulternative pharmacological tool for treatment of neuropathic pain that is largely refractory to standard analgesics such as pregabalin.

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Published

2013-03-01

How to Cite

Goyal, S., Khilnani, G., Bais, C. S., Singhvi, I., Singla, S., Patel, H., & Khilnani, A. K. (2013). EFFECT OF ZONISAMIDE ON CHRONIC CONSTRICTION INJURY INDUCED NEUROPATHIC PAIN IN MALE SD RATS. Asian Journal of Pharmaceutical Research and Development, 1(2), 150–159. Retrieved from https://www.ajprd.com/index.php/journal/article/view/65

Issue

Section

Research Articles