Comparison Effect of Natural and Synthetic Superdisintigrants In Fast Dissolving Tablet Formulation
DOI:
https://doi.org/10.22270/ajprd.v8i5.775Keywords:
Levofloxacin HCL, Fenugreek, Crosscarmellose sodium, Cross povidone , Sodium starch glycolate.Abstract
The main object of the recent and present study is to develop the oral fast disintegrating tablets of levolfloxacin HCL using natural and synthetic disintegrants in order to find out the difference in drug release from the dosage form levofloxacin is an antibiotic which is used to treat number bacterial infection including , pneumonia ,urinary tract infections,chronicprostatitis and some type of gastroenteritis.we prepared levofloxacin HCL superdisintegranting tablet to treat bacterial infections.we studied the use of natural and synthetic disintrgrants in the preparation of levofloxacin tablet. The present study comprise all information of superdisintigrants including its type , mechanism ,selection criteria ,ideal properties incorporation method and advantage which are being used in the formulation to provide the safer ,effective drug delivary with patients compliance.
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2. M. P. Khinchi, M. K. Gupta, A. Bhandari, D. Agarwal& N. Sharma. Studies on theDisintegrant Properties Of Seed Powder, Husk Powder And Mucilage Of PlantagoOvata By Formulation Of Orally Disintegrating Tablet. International Journal of Pharmaceutical Sciences and Research. 2011; 2:145-152.
3. G. Jyothi& P. K. Lakshmi. Comparative evaluation of natural and synthetic superdisintegrants with newer superdisintegrantKyron T-314. ActaPharmaceuticaSciencia. 2011:35-44.
4. R.Deveswaran, S.Bharath, S. Furtado, B.V.Basavaraj, S. Abraham &V.Madhavan. Studies on the Disintegrant properties of Mucilage and Seed Powder of Plantagoovata. International Journal of ChemTech Research. 2009; 1:621-626.
5. S. Shirsand, S. Suresh, M. Para, P. Swamy& D. N. Kumar. Plantagoovata mucilage in the design of fast disintegrating tablets. Indian Journal OfPhrmaceutical Science. 2009; 71:41-45.
6. K. K. Mehta, H. H. Patel, N. D. Patel, C. N. Vora& N. J.Patel. Comparative Evaluation of Natural And Synthetic Superdisintegrant For Promoting Nimesulide Dissolution For Fast Dissolving Technology. International Journal Of Pharmacy And Pharmaceutical Sciences. 2010; 1:102-108.
7. N. Bansal& G. Sharma. Formulation and Evaluation of Orally Disintegrating Tablets OfOndansetron Hydrochloride Using Natural Superdisintegrants. International Journal ofPharmtech Research, IJPRIF. 2011: 1616-1621.
8. C.K. Kokate, PurohitAP,Gokhle SB, Pharmacognosy , Thirteen ed., NiraliPrakashan, New Delhi, 2005.
9. Kashyap S, Sharma V, Singh L, Fast disintegrating table: A boon to pediatric and geriatric. Imperial Journal of Pharmaceutics & Cosmetology, 2011; 1(1):1-11.
10. Pahwa R, Piplani M, Sharma PC, Kaushik D, Nanda S, Orally Disintegrating Tablets: Friendly to Pediatrics and Geriatrics. Journal of Applied Science Research, 2010; 2 (2):35-48.
11. BhowmikDebjit, Chiranjib B, Kant Krishna, Pankaj, R. Margret Chandira: Fast Dissolving Tablet: An Overview. Journal of Chemical and Pharmaceutical Research, 2009; 1(1):163-177.
12. Shukla Dali, ChakrabortySubhashis, Singh Sanjay, MishraBrahmeshwar: Mouth Dissolving Tablets: An Overview of Formulation Technology. ScientiaPharmceutica. 2009; 77:309– 326.
13. Mohanachandran P.S, Sindhumol P.G, Kiran T.S. Superdisintegrants: An overview, International Journal of Pharmaceutical Sciences Review and Research 2011; 6:105-109.
14. Pebley W.S., Jager N.E., Thompson S.J., (1994), Rapidly disintegrating tablets, US Patent No.5, 298,261.
15. European Pharmacopoeia, (2002), 4th Edition, Supplement 4.2, 2435 9. Lindgren S., Janzon L,1993.
16. Nandy B.C, Bhaskar M, Pathak K, Saxena N, Jain S, Sharma S, Shrivastava A., Saxena P. Fast dissolvingdrug delivery system. Asian Journal of pharmaceutical sciences and research. 2011; 1(2):1-30.
17. Kuchekar BS, Bhise SB, Arumugam V, Design of fast disintegrating tablets. Indian J Pharm Educ.2001; 35(4):150-2.
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