Evaluation of Hepatoprotective Activity of Leaves Extract of Pithecellobium Dulce In Experimental Animals
DOI:
https://doi.org/10.22270/ajprd.v9i4.985Keywords:
Pithecellobium dulce ,Hepatotoxicity,Silymarin,Paracetamol, SGOT,SGPT,ALPAbstract
Objective: To evaluate the hepatoprotective activity of leaves extract of Pithecellobiumdulce in experimental rats.
Methods: For the generation of Hepatotoxicity ,paracetamol (2g/kg) was administered orally for 7days, accompanied by a 7-day dose of Ethanolic extract of Pithecellobiumdulceleaves(100mg/kg, 200mg/kg, and400mg/kg, p.o.)using 1 % w/v CMC as a vehicle.
Results: From the present investigation, it was observed that ethanolic extract of Pithecellobium dulce have shown significant reduction in serum glutamate oxaloacetate transminase (SGOT),serum glutamate pyruvate transminase (SGPT),alkaline phosphatase (ALP) triglyceride, bilirubin level in paracetamol induced hepatotoxicity.
Conclusion: The findings in this study revealed the effectiveness of ethanolic extract of Pithecellobiun dulce against hepatotoxicity activity.
Downloads
References
2. TortoraG.J,GrabowskiS.R.PrinciplesofAnatomyandPhysiology.8thed.Newyork:Harper Collins College;1996.p.824.
3. Junqueira LC, Carneiro J. Basic Histology Text and Atlas.10th ed .New York :Lnage medical books,McGraw Hill company;2003.p.332-343.
4. Ward F.M, Daly M.J; Hepatic disease.InWalkarR,Edward C, editors;clinical pharmacy and therapeutics .Churchi lLivingston,New York,1999;195-212.
5. Friedman SE,Grendell JH,Quaid M,Kenneth R.Current diagnosis and treatment in gastroenterology .Lang Medical Books/Mc Graw -Hill.New York,2003;p.664-679.
6. Pang S, Xin X Stipierre MV.Determinants of metabolic disposition .Ann Pharmacol Toxicol.1992;32. 625-626.
7. Hiwale Shrikant.Non Traditional Crops:Manila Tamarind(Tamarindus Indica Linn).Sustainable Horticulture in Semiarid Dry Lands.2015;p.273-277.
8. Orwa CA Mutua, Kindt R, Jamnadass R, Anthony S. Agroforestree Database: a tree reference and selection guide version 4.0.2009.(http://www.worldagroforestry.org/sites/treedbs/tree data bases.asp).
9. Adinarayana D ,Chetty PR. Chemical investigation of some medicinal plants occcuring in southern India.Indian Journal of chemical Technology.1985;24B:453.
10. Sugumaran M,Vetrichelvan T,and Darlin Quine S.Antidiarrhoeal actvity on leaf extracts of Pithecellobium dulce.Biosciences Biotechnology Research Asia.2008;5(1):421-424.
11. Sugumaran M ,Vetrichelvan T, Darlin Quine S.Anticonvulsant actvity of folklare:Pithecellobium dulce benth. Biomedical and Pharmacology Journal.2008;1(1):223-225.
12. Govindrajan Marimuthu,Mohan Rajeswaryl,Hoti SL,Giovanni Benelli.Amsath A.Adulticidal Activity of Pithecellobium dulce (Roxb.)Benth.and Delonix Elata(L) Gamble(Family:Fabaceae) Against The Malaria Vector Anopheles Stepgensi (Liston)(Diptera:Culicadae).International Journal of Pure and Applied Zoology.2015;3(3):274-278.
13. Sundar rajan T, Raj Kumar T,Udhayankumar E and Arunachalan G.Hypolipidemic activity of Pithecellobium dulce Benth. in triton induced Wr-1339 induced hyperlipidemic rats.Journal of Chemical and Pharmaceutical Sciences.2010;1(2):50-53.
14. Katekhaye Shankar H,Kale Maheshkumar S.Antioxidant and free radical scavenging activity of Pithecellobium dulce (Roxb)Benth wood bark and leaves.Free Radicals and Antioxidants.2012;2(3):47-57.
15. Mule VS, Naikwade NS, Magdum CS, Jagtap VA. Antidiabetic activity of extracts of Pithecellobium dulce Benth leaves in Alloxan induced diabetic rats.International Journal of Pharmaceutical Sciences and Drug Research.2016; 8(5):275-280.
16. Kumari Suman.Evaluation of phytochemical analysis and antioxidant and antifungal activity of Pithecellobium dulce leaves extract.Asian Journal of Pharmaceutical and Clinical Research.2017; 10(1):370-375.
17. Selvan Atul S,P Mukthukumaran.Analgesic and anti-inflammatory activities of leaf extract of Pithecellobium dulce Benth, International journal of PharmaTech research.2011; 3(1):337-341.
18. M Govindarajan, M Rajeshwary, and R Sivakumar.Larvicidal and ovicidal efficacy of Pithecellobium dulce(Roxb.) Benth.(Fabaceae) against Anopheles stephensi.IndianJournal of Medical Research.2013; 138(1):129-134.
19. Kumar Mukesh, Nehra Kiran.Anti-Microbial activity of crude extracts of Pithecellobium dulce bark against various human pathogenic microbes.World Journal of Pharmacy and Pharmaceutical Science.2014; 3(5):1244-1260.
Published
How to Cite
Issue
Section
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.