An Overview on Novel Drug Delivery System of Microsphere and its Types, Materials, Method of Preparation
Keywords:
Microspheres, Drug delivery, types of microspheres, Method of preparation,Abstract
Today, there is a lot of interest in medication delivery systems based on microspheres. Microspheres can be created using both natural and artificial polymers and are typically free-flowing powders. The microspheres' diameters range from 1 to 1000 m. In microspheres, the medicine is evenly spread, dissolved, or suspended in a matrix system. Drugs that are either solid or liquid are dissolved or disseminated in a matrix system in microspheres. The current review gives a thorough overview of recent and innovative advancements on microsphere forms that have been claimed to boost bioavailability, improve stability, lengthen biological half-life, and lessen drug toxicity. Many different proteins and peptide compounds can be delivered effectively by microsphere. Microspheres come in a variety of forms, including bioadhesive, magnetic, polymeric, floating, and floating microspheres. In order to create microspheres, a variety of techniques are employed, including simple emulsion-based, double emulsion-based, interfacial deposition, interfacial polymerisation, phase separation, and spray drying. Through a variety of delivery methods, including oral, topical, naso-pulmonary, and gene therapy, microspheres administer the medication in a regulated manner. Due to their ability to encapsulate a variety of medications, biocompatibility, high bioavailability, and continuous drug release nature, polymeric based microspheres serve as ideal carriers for several controlled delivery applications. As a result, by creating novel procedures, it can increase therapeutic results and enhance drug safety. The development of microspheres has been linked to improvements in the drug's stability, bioavailability, biological half-life, and toxicity.
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References
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39. Li SP, Kowalski CR., Feld KM., Grim WM. Recent Advances in Microencapsulation Technology and Equipment, Drug Delivery Ind. Pharm.1988; 353-76.
40. Mathew Sam T, Devi Gayathri S, Prasanthv VV, Vinod B. NSAIDs as microspheres, The Internet Journal of Pharmacology. 2008;6: 11-15.
41. Pradesh TS, Sunny M., Varma KH, Ramesh P. Preparation of microstructured hydroxyapatite microspheres using oil in water emulsion, Bull Matter. Sci. 2005; 28(5): 383- 90.
42. Punitha S, Girish Y. Polymers in mucoadhesive buccal drug delivery system. International Journal of Research and Pharmaceutical Sciences 2010; 1(2): 170-186.
43. Gavin PA, Laverty TP, Jones DS. Mucoadhesive Polymeric Platforms for Controlled Drug Delivery. European Journal of Pharmaceutics and Biopharmaceutics 2009; 71: 505-518.
44. Ganga S. Mucosal Drug Delivery. Pharmainfo.net 2007; 5.
45. Sachan NK, Bhattacharya A. Basic and Therapeutic Potential of Oral Mucoadhesive Microparticulate Drug Delivery Systems. International Journal of Pharmaceutical and Clinical Research 2009; 1: 10- 14.
46. Moy AC, Mathew ST, Mathapan R, Prasanth VV. Microsphere-An Overview. International Journal of Pharmaceutical and Biomedical Sciences 2011; 2(2): 332-338.
47. Lehr CM, Bouwstra JA, Sahacht EH, Junginger HE. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. International Journal of Pharmaceutics 1992; 78: 43-48.
48. Ranga KV, Buri P. A novel in situ method to test polymers and coated for microparticles bioadhesion . International Journal of Pharmaceutics 1989; 52: 265.
49. Masareddy RS, Bolmal UB, Patil BR, Shah V. Metformin Hcl loaded sodium alginate floating microspheres prepared by ionotropic gelation technique. Indian Journal of Novel Drug Delivery 2011; 3(2): 125-133.
50. Yellanki SK, Singh J, Syed JA, Bigala R, Garanti S. Design and characterization of Amoxicillin trihydrate mucoadhesive microspheres. International Journal of Pharmaceutical Science and Drug Research 2010; 2(6): 112-114.
51. Khazaeli P, Pardakhty A, Hassanzadeh F. Formulation of Ibuprofen Beads by Ionotropic Gelation. Iranian Journal of Pharmaceutical Research 2008; 7(3):163-170.
52. Kalyankar TM, Nalanda T, Mubeena K, Hosmani A, Sonawane A. International Journal of Pharma World Research 2010; 1(3): 1-14.
53. Pavanveena C, Kavitha K, Kumar A, Formulation and evaluation of Trimetazidine Hydrochloride loaded chitosan microspheres. International Journal of Applied Pharmaceutics 2010; 2(2): 11-14.
54. Das MK, Senapati PC. Furosemide loaded alginate microspheres prepared by ionic cross linking technique. International Journal of Pharmaceutial Sciences 2008; 70(1): 77-84.
55. Kumar TM, Paul W, Sharma CP, Kuriachan MA. Bioadhesive pH Responsive Micromatrix for oral drug delivery of insulin. 2005; 18(2): 198-202.
56. Venkateshwaramurthy N, Sambathkumar R, Vijaybaskaran M. Formulation and evaluation of Furazolidine mucoadhesive microspheres. International Journal of Pharmacy and Pham Sciences 2010; 2(3): 104-106.
57. Parsad BSG, Setty CM, Gupta VRM, Devi RM. Scholars Research Library. (2011).
58. ShadabMd, Ahuja A, Khar RK, Baboota S, Mishra AK, Ali Javed. Gastroretentive drug delivery system of acyclovir-loaded alginate mucoadhesive microspheres. www.informahealthcare.com 2011; 18(4). 255-264.
59. Patil B, Gawali VU, Hardikar SR, Bhosale AV. Preparation and evaluation of mucoadhesive microspheres of atenolol and propranolol. International Journal of Pharm Tech Research 2009; 1(3): 639-643.
60. Jaiswal D, Bhattacharya A, Yadav IK, Singh HP, Chandra D, Jain D.A. Formulation and evaluation of oil entrapped floating alginate beads of rantidine hydrochloride. International Journal of Pharmacy and Pharmaceutical Sciences 2009; 1(1): 128-140.
61. Patel JK, Patel RP, Amin AF, Patel MM. Formulation and evaluation of mucoadhesive glipizide microspheres. AAPS PharmSciTech 2005; 6.
62. Mohammed GA, Satish KB, Kiran KG. Formulation and evaluation of gastric mucoadhesive drug delivery system of captopril. Journal of Current pharmaceutical research 2010; 2(1): 26-32.
63. Sivakumar R, Rajendran NN, Narayanan N. Design of mucoadhesive hydrophilic beads entrapped with ketoprofen for delivery into small intestine. Research Journal of Pharmaceutical, Biological and Chemical Sciences 2011; 2(1): 706-713.
64. Prasanth VV, Chakarabarty A, Mathew TS, Mathappan R, Kamalakkannan V, Formulation and evaluation of salbutamol sulphate microspheres by solvent evaporation method. Journal of Applied Pharmaceutical Sciences 2011; 1(5): 133-137.
65. Mishra B, Sahoo S, Biswa PK, Sahu SK, Behera BC, Jana GK. Formulation and Evaluation of Torsemideintragastric buoyant sustained release microspheres. Journal of Pharmacy Research 2010; 3(2): 742-746.
66. Verma A, Tripathi A, Shubini AS, Shailendra S. Fabrication and evaluation of sustained release microspheres of ketorolac tremethamine. International Journal of Pharmacy and Pharmaceutical Sciences 2010; 2(4): 44-48.
67. Kannan K, Karar PK, Manavalan R. Formulation and evaluation of sustained release microspheres of acetazolamide by solvent evaporation technique. Journal of Phamaceutical Sciences and Research 2009; 1(1): 36-39.
2. Ganesan P, Jonson AJD. Review on microspheres. Am J Drug Discovery Dev 2014;4:153-79.
3. Whelehan M, Marison IW. Microencapsulation using vibrating technology. J Microencapsul 2011;28:669–88.
4. Yang Q, Forrest L. Drug delivery to the lymphatic system. In: Wang B, Hu L, Siahaan TJ. editors. Drug Delivery Principles and Applications. 2nd ed. Hoboken: John Wiley and Sons Inc; 2016. p. 503-48.
5. Kadam N. R., Suvarna V. Microspheres: A Brief Review. Asian J of Biomedical and Pharmaceutical Sci, 5(47); 2015: 13-19.
6. Joseph S and Selvin CDS. Formulation and evaluation of losartan microspheres. Int J Res Pharmacy Chem. 2015; 5(4): 555-563.
7. Sharma N, Purwar N and Gupta PC. Microspheres as drug carriers for controlled drug delivery: a review. Int J Pharm Sci Res. 2015; 6(11): 4579-4578.
8. Shanthi NC, Gupta R, Mahato KA, Traditional and Emerging Applications of Microspheres: A Review, International Journal of Pharm. Tech Research. 2010; 2(1):675- 81.
9. Shanthi N.C., Dr.Gupta R., Mahato K.A., Traditional and Emerging Applications of Microspheres: A Review, International Journal of Pharm Tech Research. 2010; 2(1):675- 681.
10. Najmuddin M., Ahmed A., Shelar S., Patel V., Khan T., Floating Microspheres Of Ketoprofen :Formulation and Evaluation, International Journal Of Pharmacy and Pharmaceutical sciences. 2010; 2(Suppl2):83-87.
11. Lengyel M, KallaiSazabo, N Microparticles. Microspheres and microcapsules for advanced drug delivery. Sci Pharm 2019;87:1-31.
12. Senthil A. Mucoadhesive microspheres. Int J Pharm Res Ayurveda Pharm 2011;2:55-9.
13. Lohani A, Chaudhary GP. Mucoadhesive microspheres: a novel approach to increase gastroretention. Chron Young Sci 2012;3:121-8.
14. Deshmukh MT, Mohite SK. Preparation and evaluation of mucoadhesive microsphere of fluoxitine HCL. Int J Pharm Sci Res 2017;8:3776-85.
15. Samanta K.M., Tamilvanan S., Babu K., Suresh B., Formulation and Evaluation of Chlorpromazine Hydrochloride Loaded Self- Cross-Linked Gelatin Microcapsules, Indian Journal of pharmaceutical Sciences. 1997; 59(2):68-74.
16. Chowdary K.P.R., Koteshwara R.N., Malathi K.., Ethyl Cellulose Microspheres of Glipizide: Charecterization, InVitro and In Vivo Evaluation, Indian Journal of pharmaceutical Sciences. 2004; 66(4): 412- 416.
17. KalyanShweta, Sharma Parmod Kumar et al. Recent Advancement In Chitosan Best Formulation And Its Pharmaceutical Application. Pelagia Research Library. 2010;1(3):195-210.
18. Dr. Fishers Microsphere Selection Bangs laboratories inc, Tech Notes 201 A, 1-4 Available from URL http://www.bangslabs.com/sites/def ault/files/bangs/do cs/pdf/201A.pdf
19. P. Dutta, J.Struti, Ch. Niranajanpatra, M.E. Bhaojirao, Floating Microsphere: Recents Trends in the Development of Gastroretentive Floating Drug Delivery System. International Journal of Pharmaceutical Science and nanotechnology, 4(1), 2011, 1293-1306.
20. Y. Kawashima, T. Niwa, H. Takeuchi, T. Hino, Y. Ito, Preparation of multiple unit hollow microspheres (microbal loons) with acrylic resin containing tranilast and their drug release characteristics (in vitro) and floating behavior (invivo). J. Control. Release, 16, 1991, 279- 290.
21. Kawatra M., Jain U., Ramana J., Recent advances in floating microspheres as gastroretentive drug delivery system: A review, IJRAPR. 2012; 2(3): 5-23.
22. Dupinder K., Seema S., Gurpreet S., Rana A.C., Biodegradable microspheres: A review, IRJP.2012; 3(12):23-27.
23. Prasanth v.v., Moy A. C., Mathew S. T., Mathapan R., Microspheres: An overview, Int. J. Res. Pharm. Biomed. Sci., 2011; 2: 3328.
24. Saralidze K., Koole L.H., Knetsch M. L. W., Polymeric microspheres for medical applications, Materials. 2010; 3: 3537-64.
25. Trivedi P, Verma AML and Garud N: Preparation and Characterization of Aceclofenac Microspheres. Asian Journal of Pharmaceutics 2008; 2:110-115.
26. Pandey K, Prajapati G and Patel MR: A Review on Microspheres. International Journal of Pharmaceutical Sciences 2012; 2:53-57.
27. Prasanth VV, Chakraborty A, Mathew ST, Mathappan R and Kamalakkannan V. Formulation and evaluation of Salbutamol sulphate microspheres by solvent evaporation method. Journal of Applied Pharmaceutical Science 2011; 1:133-137.
28. Sahu M, Satapathy T, Bahadur S, Saha S, Purabiya P, Kaushik S, et al. Preparation methods for nanoparticle: A smart carrier system for treatment of cancer. March 2018; 7(19): 216- 26.
29. Madhav NVS and Kala S: Review on microparticulate drug delivery system. International Journal of Pharm Tech Research 2011; 3:1242-1254.
30. Parmar H, Bakhliwal S and Gujhrati N et al: Different methods of formulation and evaluation of Mucoadhesive microspheres. International Journal of Applied Biology and Pharmaceutical Technology. 2010; 1: 1160-1163.
31. Dixit M, Kulkarni PK, Kini AG and Shivakumar HG. Spray Drying: A crystallization Technique: A review. Int J Drug Formulation and Res. 2010; 1: 1-29
32. Patel N. R., Patel D. A., Bharadia P.D., Pandya V., Modi D. Microsphere as a novel drug delivery. Int J Pharm. Life Sci. 201; 2(8): 992-7.
33. Parmar H, Bakliwal S, Gujarathi N, Rane B, and Pawar S. Different methods of formulation and evaluation of mucoadhesive microsphere. Int J Applied Bio Pharm Tech. Nov, 2010; 1(3): 1157-67.
34. Pachuau L, Bhaskar M. A study on the effects of different surfactants on ethyl cellulose microspheres. Int J Pharm Tech 2009; 4: 966-71.
35. Kavanagh N, Corrigan OI. Swelling and erosion properties of hydroxypropylmethylcellulose (Hypromellose) matrices--influence of agitation rate and dissolution medium composition. Int J Pharm 2004; 279(1-2): 141-52
36. Trivedi P, Verma AML, Garud N. Preparation and Characterization of Acclofenac Microspheres, Asian Journal of pharmaceutics. 2008;2(2): 110-15.
37. Kreuter J, Nefzger M, Liehl E, Czokr. And Voges R. Polymer sci. and tech. J. Pharm. sci.(1983) 72, 1146.
38. Dandagi MP, Masthiolimath SV, Gadad PA, Iliger R.S. Mucoadhesive Microspheres of Propanalol Hcl for Nasal Delivery, Indian Journal of pharmaceutical Sciences. 2007;69 (3): 402-07.
39. Li SP, Kowalski CR., Feld KM., Grim WM. Recent Advances in Microencapsulation Technology and Equipment, Drug Delivery Ind. Pharm.1988; 353-76.
40. Mathew Sam T, Devi Gayathri S, Prasanthv VV, Vinod B. NSAIDs as microspheres, The Internet Journal of Pharmacology. 2008;6: 11-15.
41. Pradesh TS, Sunny M., Varma KH, Ramesh P. Preparation of microstructured hydroxyapatite microspheres using oil in water emulsion, Bull Matter. Sci. 2005; 28(5): 383- 90.
42. Punitha S, Girish Y. Polymers in mucoadhesive buccal drug delivery system. International Journal of Research and Pharmaceutical Sciences 2010; 1(2): 170-186.
43. Gavin PA, Laverty TP, Jones DS. Mucoadhesive Polymeric Platforms for Controlled Drug Delivery. European Journal of Pharmaceutics and Biopharmaceutics 2009; 71: 505-518.
44. Ganga S. Mucosal Drug Delivery. Pharmainfo.net 2007; 5.
45. Sachan NK, Bhattacharya A. Basic and Therapeutic Potential of Oral Mucoadhesive Microparticulate Drug Delivery Systems. International Journal of Pharmaceutical and Clinical Research 2009; 1: 10- 14.
46. Moy AC, Mathew ST, Mathapan R, Prasanth VV. Microsphere-An Overview. International Journal of Pharmaceutical and Biomedical Sciences 2011; 2(2): 332-338.
47. Lehr CM, Bouwstra JA, Sahacht EH, Junginger HE. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. International Journal of Pharmaceutics 1992; 78: 43-48.
48. Ranga KV, Buri P. A novel in situ method to test polymers and coated for microparticles bioadhesion . International Journal of Pharmaceutics 1989; 52: 265.
49. Masareddy RS, Bolmal UB, Patil BR, Shah V. Metformin Hcl loaded sodium alginate floating microspheres prepared by ionotropic gelation technique. Indian Journal of Novel Drug Delivery 2011; 3(2): 125-133.
50. Yellanki SK, Singh J, Syed JA, Bigala R, Garanti S. Design and characterization of Amoxicillin trihydrate mucoadhesive microspheres. International Journal of Pharmaceutical Science and Drug Research 2010; 2(6): 112-114.
51. Khazaeli P, Pardakhty A, Hassanzadeh F. Formulation of Ibuprofen Beads by Ionotropic Gelation. Iranian Journal of Pharmaceutical Research 2008; 7(3):163-170.
52. Kalyankar TM, Nalanda T, Mubeena K, Hosmani A, Sonawane A. International Journal of Pharma World Research 2010; 1(3): 1-14.
53. Pavanveena C, Kavitha K, Kumar A, Formulation and evaluation of Trimetazidine Hydrochloride loaded chitosan microspheres. International Journal of Applied Pharmaceutics 2010; 2(2): 11-14.
54. Das MK, Senapati PC. Furosemide loaded alginate microspheres prepared by ionic cross linking technique. International Journal of Pharmaceutial Sciences 2008; 70(1): 77-84.
55. Kumar TM, Paul W, Sharma CP, Kuriachan MA. Bioadhesive pH Responsive Micromatrix for oral drug delivery of insulin. 2005; 18(2): 198-202.
56. Venkateshwaramurthy N, Sambathkumar R, Vijaybaskaran M. Formulation and evaluation of Furazolidine mucoadhesive microspheres. International Journal of Pharmacy and Pham Sciences 2010; 2(3): 104-106.
57. Parsad BSG, Setty CM, Gupta VRM, Devi RM. Scholars Research Library. (2011).
58. ShadabMd, Ahuja A, Khar RK, Baboota S, Mishra AK, Ali Javed. Gastroretentive drug delivery system of acyclovir-loaded alginate mucoadhesive microspheres. www.informahealthcare.com 2011; 18(4). 255-264.
59. Patil B, Gawali VU, Hardikar SR, Bhosale AV. Preparation and evaluation of mucoadhesive microspheres of atenolol and propranolol. International Journal of Pharm Tech Research 2009; 1(3): 639-643.
60. Jaiswal D, Bhattacharya A, Yadav IK, Singh HP, Chandra D, Jain D.A. Formulation and evaluation of oil entrapped floating alginate beads of rantidine hydrochloride. International Journal of Pharmacy and Pharmaceutical Sciences 2009; 1(1): 128-140.
61. Patel JK, Patel RP, Amin AF, Patel MM. Formulation and evaluation of mucoadhesive glipizide microspheres. AAPS PharmSciTech 2005; 6.
62. Mohammed GA, Satish KB, Kiran KG. Formulation and evaluation of gastric mucoadhesive drug delivery system of captopril. Journal of Current pharmaceutical research 2010; 2(1): 26-32.
63. Sivakumar R, Rajendran NN, Narayanan N. Design of mucoadhesive hydrophilic beads entrapped with ketoprofen for delivery into small intestine. Research Journal of Pharmaceutical, Biological and Chemical Sciences 2011; 2(1): 706-713.
64. Prasanth VV, Chakarabarty A, Mathew TS, Mathappan R, Kamalakkannan V, Formulation and evaluation of salbutamol sulphate microspheres by solvent evaporation method. Journal of Applied Pharmaceutical Sciences 2011; 1(5): 133-137.
65. Mishra B, Sahoo S, Biswa PK, Sahu SK, Behera BC, Jana GK. Formulation and Evaluation of Torsemideintragastric buoyant sustained release microspheres. Journal of Pharmacy Research 2010; 3(2): 742-746.
66. Verma A, Tripathi A, Shubini AS, Shailendra S. Fabrication and evaluation of sustained release microspheres of ketorolac tremethamine. International Journal of Pharmacy and Pharmaceutical Sciences 2010; 2(4): 44-48.
67. Kannan K, Karar PK, Manavalan R. Formulation and evaluation of sustained release microspheres of acetazolamide by solvent evaporation technique. Journal of Phamaceutical Sciences and Research 2009; 1(1): 36-39.
Published
2023-08-13
How to Cite
Joshi, V., Velhal, A., Patil, S., Redasani, V., Raut, P., & Bhosale, N. (2023). An Overview on Novel Drug Delivery System of Microsphere and its Types, Materials, Method of Preparation. Asian Journal of Pharmaceutical Research and Development, 11(4), 106–114. Retrieved from https://www.ajprd.com/index.php/journal/article/view/1290
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Review Articles
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