An Overview of Animal Models and Symptomatic Treatment of Parkinson’s disease


  • Pooja Patil YSPM’S YTC Faculty of Pharmacy, Satara
  • Vitthal Chaware YSPM’S YTC Faculty of Pharmacy, Satara
  • Vivekkumar Redasani YSPM’S YTC Faculty of Pharmacy, Satara



Parkinson disease, Models, Toxicant, Genetic, Treatment.​


The broad theory indicate that neurological ailment is caused by intricate interactions between environmental and genetic factors is supported using animal models to better understand the the cause and pathogenesis of Parkinson's disease (PD), as well as its cellular and molecular mechanisms. The more recent models use genetic manipulations that either introduce mutations similar to those found in familial cases of PD (a-synuclein, DJ-1, PINK1, Parkin, etc.) or selectively disrupt nigrostriatal neurons (MitoPark, Pitx3, Nurr1, etc.). "Classic" models are based on neurotoxins that specifically target catecholaminergic neurons. All of these together each model has its own benefits and drawbacks. The use of medication, deep brain stimulation, and physical therapy has been optimised for the symptomatic treatment of the motor symptoms of Parkinson disease (PD). L-dopa, several dopamine agonists, inhibitors of MAO-B and catechol-o-methyltransferase (COMT), and amantadine are among the pharmacotherapies available.



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Author Biographies

Pooja Patil, YSPM’S YTC Faculty of Pharmacy, Satara

YSPM’S YTC Faculty of Pharmacy, Satara

Vitthal Chaware, YSPM’S YTC Faculty of Pharmacy, Satara

YSPM’S YTC Faculty of Pharmacy, Satara

Vivekkumar Redasani, YSPM’S YTC Faculty of Pharmacy, Satara

YSPM’S YTC Faculty of Pharmacy, Satara


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How to Cite

Patil, P., Chaware, V., & Redasani, V. (2023). An Overview of Animal Models and Symptomatic Treatment of Parkinson’s disease. Asian Journal of Pharmaceutical Research and Development, 11(3), 132–135.

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