Preparation of flutrimazole micro sponge gel by quasi-emulsion solvent diffusion method

Authors

  • Gajendra Tyagi Research Scholar, Lords University, Alwar, India 301028,
  • Suresh Choudhary Professor, Faculty of Pharmacy , Lords University, Alwar, India 301028

DOI:

https://doi.org/10.22270/ajprd.v11i3.1393

Abstract

Microsponge containing Flutrimazole drug with six different proportions of Eudragit RS  100 as polymer were obtained successfully using quasi-emulsion solvent diffusion method. Particle size and physical properties of the formulations were examined. Physical properties showed that microsponge formulations MS IV and MS VI exhibited better material efficiency and  yield. Two microsponge formulations were prepared as gels in 0.35% w/w carbomer and examined for pH, viscosity, permeability, drug content, in vitro release, antibacterial activity, and in vivo antifungal activity on Rabbit skin. The viscosity of the microsponge preparation gel MFG 1 is 4390 cps, the transmission is 19.27 g cm/s, and the drug content is 85.2%. Antibiotic research shows that compared with pure drug, the inhibition zone of microsponge formulation gels MFG 1 and MFG 2 is 13.5 mm and 12.0 mm, respectively, and the inhibition zone of pure drug is 18.2 mm. These formulations also showed better antifungal activity on fungal-induced Rabbit skin compared to the no-drug control. The microsponge flutrimazole gel formulation shows a favorable drug release profile and also minimizes gel application in fungal treatment.

 

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Author Biographies

Gajendra Tyagi , Research Scholar, Lords University, Alwar, India 301028,

Research Scholar, Lords University, Alwar, India 301028,   

Suresh Choudhary , Professor, Faculty of Pharmacy , Lords University, Alwar, India 301028

Professor, Faculty of Pharmacy , Lords University, Alwar, India 301028

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Published

2024-06-15

How to Cite

Tyagi , G., & Choudhary , S. (2024). Preparation of flutrimazole micro sponge gel by quasi-emulsion solvent diffusion method . Asian Journal of Pharmaceutical Research and Development, 12(3), 43–49. https://doi.org/10.22270/ajprd.v11i3.1393

Issue

Vol. 12 No. 3 (2024): Volume 12 Issue 3 May - June. 2024

Section

Research Articles

Copyright (c) 2024 Gajendra Tyagi , Suresh Choudhary

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