ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF ROOTS OF GLYCOSMIS PENTAPHYLLA
Keywords:
Glycosmis pentaphylla, Rutaceae, Anti-inflammatoryAbstract
The plant Glycosmis pentaphylla corr. belongs to the family Rutaceae. This plant has great medicinal value and is widely distributed in India. The anti-inflammatory effect of methanolic extract of roots of G. pentaphylla was studied using carrageenan and egg albumin-induced rat paw edema, xylene induced mouse ear edema and formaldehyde induced arthritis inflammation tests at doses of 50-400 mg/kg, intra peritoneally. The extract produced a significant (P<0.05) dose dependant inhibition of edema formation in all four methods. The results of pharmacological tests performed in the present study suggest that the methanolic extract of G. pentaphylla possess anti-inflammatory effect and these findings seem to justify the use of plant in traditional Indian medicine in the treatment of inflammation.
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