ENHANCEMENT OF SOLUBILITY OF POORLY WATER SOLUBLE DRUG – METRONIDAZOLE BY HYDROTROPY

Authors

  • Aseri Ajay Maharishi arvind College of Pharmacy, Ambabari, Jaipur Rajasthan, India
  • Duggal Deepak B R Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India
  • Katewa Jitesh B R Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India
  • Nayak Anjali B R Nahata College of Pharmacy, Mandsaur, Madhya Pradesh, India

Keywords:

Metronidazole, Urea, Hydrotropy, Dissolution

Abstract

Metronidazole is an oral synthetic antiprotozoal and antibacterial agent, 2-methyl-5nitroimidazole-1-ethanol (C6H9N3O3 ). It is physically available in white to pale yellow crystals or crystalline powder with 159-1630C melting point. It is sparingly soluble in Water and in Alcohol; slightly soluble in ether and chloroform. In the present investigation different concentrated solutions of urea (a hydrotropic agent) were employed to enhance the aqueous solubility of Metronidazole which is a poorly water-soluble drug. Here hydrotropic phenomenon i.e solvent evaporation technique and melting method were employed to prepare solid dispersions of Metronidazole. Solid dispersions were evaluated for dissolution rate and a marked increase in dissolution rate was observed. Marked increase in Metronidazole release during drug dissolution profile was found with its solid dispersions as it is poorly water soluble drug. As a hydrotropic agent Urea was used to prepare solid dispersion so that the solubility of Metronidazole could be increased.

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Published

2013-05-01

How to Cite

Ajay, A., Deepak, D., Jitesh, K., & Anjali, N. (2013). ENHANCEMENT OF SOLUBILITY OF POORLY WATER SOLUBLE DRUG – METRONIDAZOLE BY HYDROTROPY. Asian Journal of Pharmaceutical Research and Development, 1(2), 98–102. Retrieved from https://www.ajprd.com/index.php/journal/article/view/33

Issue

Volume 1st Issue 3rd May-June 2013

Section

Research Articles

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